David C Hughes
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Explore the profile of David C Hughes including associated specialties, affiliations and a list of published articles.
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Recent Articles
1.
Lord S, Dawson P, Chunthorng-Orn J, Ng J, Baehr L, Hughes D, et al.
Biochem Biophys Rep
. 2024 Jan;
37:101636.
PMID: 38283190
MuRF1 (Muscle-specific RING finger protein 1; gene name TRIM63) is a ubiquitin E3 ligase, associated with the progression of muscle atrophy. As a RING (Really Interesting New Gene) type E3...
2.
McAuley A, Hughes D, Tsaprouni L, Varley I, Suraci B, Bradley B, et al.
J Strength Cond Res
. 2024 Jan;
38(2):350-359.
PMID: 38258831
McAuley, ABT, Hughes, DC, Tsaprouni, LG, Varley, I, Suraci, B, Bradley, B, Baker, J, Herbert, AJ, and Kelly, AL. Genetic associations with acceleration, change of direction, jump height, and speed...
3.
Hughes D, Goodman C, Baehr L, Gregorevic P, Bodine S
Am J Physiol Cell Physiol
. 2023 Nov;
325(6):C1567-C1582.
PMID: 37955121
Ubiquitination is an important post-translational modification (PTM) for protein substrates, whereby ubiquitin is added to proteins through the coordinated activity of activating (E1), ubiquitin-conjugating (E2), and ubiquitin ligase (E3) enzymes....
4.
Genetic Variations between Youth and Professional Development Phase English Academy Football Players
McAuley A, Hughes D, Tsaprouni L, Varley I, Suraci B, Baker J, et al.
Genes (Basel)
. 2022 Nov;
13(11).
PMID: 36360238
The purpose of this study was to examine differences in the genotype frequency distribution of thirty-three single nucleotide variants (SNVs) between youth development phase (YDP) and professional development phase (PDP)...
5.
Domaschenz R, Vlahovich N, Keogh J, Compton S, Hughes D
JMIR Res Protoc
. 2022 Oct;
4(4):e117.
PMID: 36262008
Background: Long-distance runners are prone to injuries including Achilles tendinopathy and medial tibial stress syndrome. We have developed an Internet comprehensive self-report questionnaire examining the medical history, injury history, and...
6.
Hughes D, Baehr L, Waddell D, Sharples A, Bodine S
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886949
The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part...
7.
Hughes D, Orchard J, Partridge E, La Gerche A, Broderick C
J Sci Med Sport
. 2022 Jun;
25(7):544-547.
PMID: 35725689
No abstract available.
8.
McAuley A, Hughes D, Tsaprouni L, Varley I, Suraci B, Baker J, et al.
J Sports Med Phys Fitness
. 2022 Jun;
63(2):230-240.
PMID: 35666584
Background: Technical capabilities have significant discriminative and prognostic power in youth football. Although, many factors influence technical performance, no research has explored the genetic contribution. As such, the purpose of...
9.
Hughes D, Hardee J, Waddell D, Goodman C
J Appl Physiol (1985)
. 2022 May;
133(1):41-59.
PMID: 35511722
The strategy of gene delivery into skeletal muscles has provided exciting avenues in identifying new potential therapeutics toward muscular disorders and addressing basic research questions in muscle physiology through overexpression...
10.
Baehr L, Hughes D, Waddell D, Bodine S
Cell
. 2022 Apr;
185(9):1618-1618.e1.
PMID: 35487192
Skeletal muscle size is highly plastic and sensitive to a variety of stimuli. Muscle atrophy occurs as the result of changes in multiple signaling pathways that regulate both protein synthesis...