Adam P. Sharples
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Explore the profile of Adam P. Sharples including associated specialties, affiliations and a list of published articles.
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52
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1198
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Recent Articles
11.
Stewart C, Sharples A
Plast Reconstr Surg
. 2022 Sep;
150:27S-33S.
PMID: 36170433
We are living in an aging society. In 2019, 1 billion individuals were already aged over 60. The number of people in this demographic is predicted to reach 1.4 billion...
12.
Hughes D, Baehr L, Waddell D, Sharples A, Bodine S
Int J Mol Sci
. 2022 Jul;
23(14).
PMID: 35886949
The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part...
13.
14.
Ruple B, Godwin J, Mesquita P, Osburn S, Vann C, Lamb D, et al.
FASEB J
. 2021 Aug;
35(9):e21864.
PMID: 34423880
Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males...
15.
Voisin S, Jacques M, Landen S, Harvey N, Haupt L, Griffiths L, et al.
J Cachexia Sarcopenia Muscle
. 2021 Jul;
12(4):1064-1078.
PMID: 34196129
Background: Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods: We conducted a large-scale epigenome-wide association study...
16.
Maasar M, Turner D, Gorski P, Seaborne R, Strauss J, Shepherd S, et al.
Front Physiol
. 2021 Mar;
12:619447.
PMID: 33679435
The methylome and transcriptome signatures following exercise that are physiologically and metabolically relevant to sporting contexts such as team sports or health prescription scenarios (e.g., high intensity interval training/HIIT) has...
17.
Turner D, Gorski P, Seaborne R, Viggars M, Murphy M, Jarvis J, et al.
J Cell Physiol
. 2021 Feb;
236(9):6534-6547.
PMID: 33586196
Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether...
18.
Hughes D, Turner D, Baehr L, Seaborne R, Viggars M, Jarvis J, et al.
Am J Physiol Cell Physiol
. 2020 Oct;
320(1):C45-C56.
PMID: 33052072
UBR5 is an E3 ubiquitin ligase positively associated with anabolism, hypertrophy, and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5's role in the regulation of skeletal muscle...
19.
Hearris M, Owens D, Strauss J, Shepherd S, Sharples A, Morton J, et al.
Exp Physiol
. 2020 Aug;
105(11):1882-1894.
PMID: 32862503
New Findings: What is the central question of this study? What is the absolute level of pre-exercise glycogen concentration required to augment the exercise-induced signalling response regulating mitochondrial biogenesis? What...
20.
Seaborne R, Sharples A
Exerc Sport Sci Rev
. 2020 Jul;
48(4):188-200.
PMID: 32658040
We explore work from within the field of skeletal muscle and across the broader field of molecular biology, to propose that the link between exercise and skeletal muscle adaptation lies...