Adam H Metherel
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Explore the profile of Adam H Metherel including associated specialties, affiliations and a list of published articles.
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66
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631
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Recent Articles
11.
Rotarescu R, Rezaei K, Mutch D, Metherel A
Prostaglandins Leukot Essent Fatty Acids
. 2022 Sep;
185:102494.
PMID: 36148741
Dietary feeding and stable isotope studies in rodents support that the 24-carbon omega-3 polyunsaturated fatty acids, tetracosapentaenoic acid (24:5n-3, TPAn-3) and tetracosahexaenoic acid (24:6n-3, THA), are immediate precursors to docosahexaenoic...
12.
Liu J, Sahin C, Ahmad S, Magomedova L, Zhang M, Jia Z, et al.
Sci Signal
. 2022 Jul;
15(741):eabo1857.
PMID: 35857636
The nuclear receptor peroxisome proliferator-activated receptor alpha (PPARα) is emerging as an important target in the brain for the treatment or prevention of cognitive disorders. The identification of high-affinity ligands...
13.
Videla L, Hernandez-Rodas M, Metherel A, Valenzuela R
Prostaglandins Leukot Essent Fatty Acids
. 2022 May;
181:102441.
PMID: 35537354
Polyunsaturated fatty acids (PUFA) play essential roles in cell membrane structure and physiological processes including signal transduction, cellular metabolism and tissue homeostasis to combat diseases. PUFA are either consumed from...
14.
Sylvestre D, Otoki Y, Metherel A, Bazinet R, Slupsky C, Taha A
Neurochem Int
. 2022 Feb;
156:105294.
PMID: 35104537
It is known that brain energy metabolites such as ATP are quickly depleted during postmortem ischemia; however, a comprehensive assessment on the effects of preceding hypercapnia/ischemia and the dissection process...
15.
Cisbani G, Koppel A, Metherel A, Smith M, Aji K, Andreazza A, et al.
Lipids
. 2022 Jan;
57(2):125-140.
PMID: 35075659
Cannabis is now legal in many countries and while numerous studies have reported on its impact on cognition and appetite regulation, none have examined fatty acid metabolism in young cannabis...
16.
Smith M, Cisbani G, Metherel A, Bazinet R
J Neurochem
. 2021 Nov;
161(2):112-128.
PMID: 34780089
Previously, results from studies investigating if brain palmitic acid (16:0; PAM) was maintained by either dietary uptake or de novo lipogenesis (DNL) varied. Here, we utilize naturally occurring carbon isotope...
17.
Caipo L, Sandoval A, Sepulveda B, Fuentes E, Valenzuela R, Metherel A, et al.
Foods
. 2021 Sep;
10(9).
PMID: 34574270
Commercialization of extra virgin olive oil (EVOO) requires a best before date recommended at up to 24 months after bottling, stored under specific conditions. Thus, it is expected that the...
18.
Cisbani G, Metherel A, Smith M, Bazinet R
Neurochem Int
. 2021 Aug;
150:105154.
PMID: 34384851
The brain is a multicellular organ enriched with lipids. While the fatty acid composition of gross cerebral tissue is well characterized, the fatty acid composition of specific brain cells, particularly...
19.
Metherel A, Rezaei K, Lacombe R, Bazinet R
Biochim Biophys Acta Mol Cell Biol Lipids
. 2021 Apr;
1866(8):158942.
PMID: 33845223
Recent meta-analyses suggest that high eicosapentaenoic acid (EPA, 20:5n-3) supplements may be beneficial in managing the symptoms of major depression. However, brain EPA levels are hundreds-fold lower than docosahexaenoic acid...
20.
Harris W, Tintle N, Manson J, Metherel A, Robinson J
Am J Clin Nutr
. 2021 Mar;
113(6):1700-1706.
PMID: 33710263
Background: The factors other than dietary intake that determine tissue concentrations of EPA and DHA remain obscure. Prior studies suggested that, in women, endogenous estrogen may accelerate synthesis of DHA...