A Norrie Pearce
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Explore the profile of A Norrie Pearce including associated specialties, affiliations and a list of published articles.
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18
Citations
192
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Recent Articles
1.
Pearce A, Chen D, Edmeades L, Cadelis M, Troudi A, Brunel J, et al.
Bioorg Med Chem
. 2021 Apr;
38:116110.
PMID: 33831695
In our search for new antibiotic adjuvants as a novel strategy to deal with the emergence of multi-drug resistant (MDR) bacteria, a series of succinylprimaquine-polyamine (SPQ-PA) conjugates and derivatives of...
2.
Pearce A, Hill C, Page M, Keyzers R, Copp B
J Nat Prod
. 2019 Jul;
82(8):2291-2298.
PMID: 31356078
An acetylenic 2-amino-3-alcohol, distaminolyne B (), isolated from the New Zealand ascidian , is reported. The isolation and structure elucidation of and assignment of 2,3 absolute configuration (AC) using the...
3.
Molinski T, Salib M, Pearce A, Copp B
J Nat Prod
. 2019 Apr;
82(5):1183-1189.
PMID: 30958674
The 2 S configuration of the marine natural product distaminolyne A was recently disputed based upon total synthesis, yet paradoxically supported by a second independent total synthesis from a different...
4.
Pearce A, Copp B, Molinski T
Molecules
. 2018 Dec;
24(1).
PMID: 30591663
Sample configurations of distaminolyne A (); isolated from the ascidians and , and collected at different sites in New Zealand, were investigated by two methods: Exciton coupled electronic circular dichroism...
5.
Pearce A, Kaiser M, Copp B
Eur J Med Chem
. 2017 Oct;
140:595-603.
PMID: 28988153
A series of artesunate-polyamine and trioxolane-polyamine conjugates have been prepared. The conjugates were evaluated for antimalarial activity towards the K1 dual drug resistant and NF54 chloroquine-sensitive strains of Plasmodium falciparum...
6.
Davidson S, Pearce A, Copp B, Barker D
Org Lett
. 2017 Sep;
19(19):5368-5371.
PMID: 28901148
The first total synthesis of (-)-bicubebin A, and two previously unreported dilignans, (-)-bicubebin B and (+)-bicubebin C has been achieved through the dimerization of (-)-cubebin, confirming the structure and absolute...
7.
Wang J, Pearce A, Chan S, Taylor R, Page M, Valentin A, et al.
J Nat Prod
. 2015 Dec;
79(3):607-10.
PMID: 26670413
The first occurrence of an acetylenic 1-amino-2-alcohol, distaminolyne A (1), isolated from the New Zealand ascidian Pseudodistoma opacum, is reported. The isolation and structure elucidation of 1 and assignment of...
8.
Lam C, Pearce A, Tan S, Kaiser M, Copp B
Mar Drugs
. 2013 Sep;
11(9):3472-99.
PMID: 24022732
Pure compound screening has identified the dioxothiazino-quinoline-quinone ascidian metabolite ascidiathiazone A (2) to be a moderate growth inhibitor of Trypanosoma brucei rhodesiense (IC₅₀ 3.1 μM) and Plasmodium falciparum (K1 dual...
9.
Liew L, Pearce A, Kaiser M, Copp B
Eur J Med Chem
. 2013 Sep;
69:22-31.
PMID: 23995215
We recently reported that 1,14-diphenylacetamide derivatives of spermine exhibit potent nM in vitro growth inhibition properties of Plasmodium falciparum. In an effort to expand the structure-activity relationship of this compound...
10.
Lam C, Grkovic T, Pearce A, Copp B
Org Biomol Chem
. 2012 Mar;
10(15):3092-7.
PMID: 22395232
The mechanisms of action of the cytotoxic marine pyrroloiminoquinone alkaloids the discorhabdins are unknown. We have determined that discorhabdin B acts as an electrophile towards biomimetic thiol nucleophiles leading to...