A Norrie Pearce
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Explore the profile of A Norrie Pearce including associated specialties, affiliations and a list of published articles.
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Articles
18
Citations
192
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0
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Recent Articles
11.
Chan S, Pearce A, Januario A, Page M, Kaiser M, Mclaughlin R, et al.
J Org Chem
. 2011 Oct;
76(21):9151-6.
PMID: 21958335
Bioassay-directed fractionation of an extract of the New Zealand ascidian Aplidium scabellum has afforded the anti-inflammatory secondary metabolite 2-geranyl-6-methoxy-1,4-hydroquinone-4-sulfate (1) and a family of pseudodimeric meroterpenoids scabellones A (2)-D (5)....
12.
Chan S, Pearce A, Page M, Kaiser M, Copp B
J Nat Prod
. 2011 Aug;
74(9):1972-9.
PMID: 21846091
One tetrahydro-β-carboline, (-)-7-bromohomotrypargine (1), and three alkylguanidine-substituted β-carbolines, opacalines A, B, and C (2-4), have been isolated from the New Zealand ascidian Pseudodistoma opacum. The structures of the metabolites were...
13.
Finlayson R, Pearce A, Page M, Kaiser M, Bourguet-Kondracki M, Harper J, et al.
J Nat Prod
. 2011 Feb;
74(4):888-92.
PMID: 21348447
Two new indole spermidine alkaloids, didemnidines A (1) and B (2), have been isolated from the New Zealand ascidian Didemnum sp. The structures of the metabolites, determined by analysis of...
14.
Grkovic T, Pearce A, Munro M, Blunt J, Davies-Coleman M, Copp B
J Nat Prod
. 2010 Sep;
73(10):1686-93.
PMID: 20860391
Investigations of four different sponge populations of Latrunculia species collected in New Zealand waters has led to the characterization of a new diastereomer of discorhabdin H, named discorhabdin H2, confirmation...
15.
Chia E, Pearce A, Berridge M, Larsen L, Perry N, Sansom C, et al.
Bioorg Med Chem
. 2008 Oct;
16(21):9432-42.
PMID: 18835721
Sixteen new thiazine-quinoline-quinones have been synthesised, plus one bicyclic analogue. These compounds inhibited neutrophil superoxide production in vitro with IC(50)s as low 60 nM. Compounds with high in vitro anti-inflammatory...
16.
Pearce A, Chia E, Berridge M, Clark G, Harper J, Larsen L, et al.
J Nat Prod
. 2007 May;
70(6):936-40.
PMID: 17497807
Ascidiathiazones A (3) and B (4), two new tricyclic thiazine-containing quinolinequinone alkaloids, were isolated from the New Zealand ascidian Aplidium species. Both compounds inhibited the in vitro production of superoxide...
17.
Copp B, Pearce A
Nat Prod Rep
. 2007 Mar;
24(2):278-97.
PMID: 17389998
This review covers natural products (secondary metabolites) with reported growth inhibitory activity towards Mycobacterium tuberculosis or related organisms. Such compounds have been isolated from a variety of sources including terrestrial...
18.
Pearce A, Chia E, Berridge M, Maas E, Page M, Webb V, et al.
J Nat Prod
. 2007 Jan;
70(1):111-3.
PMID: 17253860
Bioassay-directed fractionation of extracts of a Synoicum n. sp. ascidian from New Zealand led to the isolation of the principal anti-inflammatory component, which was identified by spectroscopic methods as a...