A Malcolm R Taylor
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Explore the profile of A Malcolm R Taylor including associated specialties, affiliations and a list of published articles.
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Articles
42
Citations
2437
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Recent Articles
1.
Goldgraben M, Fewings E, Larionov A, Scarth J, Redman J, Telford N, et al.
Pediatr Blood Cancer
. 2020 May;
67(9):e28354.
PMID: 32383811
No abstract available.
2.
Kwok M, Oldreive C, Rawstron A, Goel A, Papatzikas G, Jones R, et al.
Blood
. 2019 Dec;
135(6):411-428.
PMID: 31794600
Spontaneous regression is a recognized phenomenon in chronic lymphocytic leukemia (CLL) but its biological basis remains unknown. We undertook a detailed investigation of the biological and clinical features of 20...
3.
Taylor A, Rothblum-Oviatt C, Ellis N, Hickson I, Meyer S, Crawford T, et al.
Nat Rev Dis Primers
. 2019 Sep;
5(1):64.
PMID: 31537806
Fanconi anaemia (FA), ataxia telangiectasia (A-T), Nijmegen breakage syndrome (NBS) and Bloom syndrome (BS) are clinically distinct, chromosome instability (or breakage) disorders. Each disorder has its own pattern of chromosomal...
4.
Agathanggelou A, Smith E, Davies N, Kwok M, Zlatanou A, Oldreive C, et al.
Blood
. 2017 May;
130(2):156-166.
PMID: 28495793
The role of deubiquitylase ubiquitin-specific protease 7 (USP7) in the regulation of the p53-dependent DNA damage response (DDR) pathway is well established. Whereas previous studies have mostly focused on the...
5.
Reynolds J, Bicknell L, Carroll P, Higgs M, Shaheen R, Murray J, et al.
Nat Genet
. 2017 Feb;
49(4):537-549.
PMID: 28191891
To ensure efficient genome duplication, cells have evolved numerous factors that promote unperturbed DNA replication and protect, repair and restart damaged forks. Here we identify downstream neighbor of SON (DONSON)...
6.
Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al.
PLoS Genet
. 2016 Mar;
12(3):e1005945.
PMID: 26990772
Patients with biallelic truncating mutations in PALB2 have a severe form of Fanconi anaemia (FA-N), with a predisposition for developing embryonal-type tumours in infancy. Here we describe two unusual patients...
7.
Oldreive C, Skowronska A, Davies N, Parry H, Agathanggelou A, Krysov S, et al.
Dis Model Mech
. 2015 Sep;
8(11):1401-12.
PMID: 26398941
Chronic lymphocytic leukaemia (CLL) cells require microenvironmental support for their proliferation. This can be recapitulated in highly immunocompromised hosts in the presence of T cells and other supporting cells. Current...
8.
Agathanggelou A, Weston V, Perry T, Davies N, Skowronska A, Payne D, et al.
Haematologica
. 2015 Apr;
100(8):1076-85.
PMID: 25840602
Inactivation of the Ataxia Telangiectasia Mutated gene in chronic lymphocytic leukemia results in resistance to p53-dependent apoptosis and inferior responses to treatment with DNA damaging agents. Hence, p53-independent strategies are...
9.
Baple E, Chambers H, Cross H, Fawcett H, Nakazawa Y, Chioza B, et al.
J Clin Invest
. 2014 Jun;
124(7):3137-46.
PMID: 24911150
Numerous human disorders, including Cockayne syndrome, UV-sensitive syndrome, xeroderma pigmentosum, and trichothiodystrophy, result from the mutation of genes encoding molecules important for nucleotide excision repair. Here, we describe a syndrome...
10.
Claes K, Depuydt J, Taylor A, Last J, Baert A, Schietecatte P, et al.
Neuromolecular Med
. 2013 May;
15(3):447-57.
PMID: 23632773
Variant ataxia telangiectasia (A-T) may be an underdiagnosed entity. We correlate data from radiosensitivity and kinase assays with clinical and molecular data from a patient with variant A-T and relatives....