Grant S Stewart
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Explore the profile of Grant S Stewart including associated specialties, affiliations and a list of published articles.
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88
Citations
3441
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Recent Articles
1.
Blanco E, Camps C, Bahal S, Kerai M, Ferla M, Rochussen A, et al.
J Exp Med
. 2024 Nov;
222(1).
PMID: 39560673
The importance of calcium (Ca2+) as a second messenger in T cell signaling is exemplified by genetic deficiencies of STIM1 and ORAI1, which abolish store-operated Ca2+ entry (SOCE) resulting in...
2.
Yang Y, Jayaprakash D, Jhujh S, Reynolds J, Chen S, Gao Y, et al.
Nucleic Acids Res
. 2024 Oct;
52(21):13019-13035.
PMID: 39445802
RNF168 orchestrates a ubiquitin-dependent DNA damage response to regulate the recruitment of repair factors, such as 53BP1 to DNA double-strand breaks (DSBs). In addition to its canonical functions in DSB...
3.
Kochenova O, DAlessandro G, Pilger D, Schmid E, Richards S, Garcia M, et al.
bioRxiv
. 2024 Sep;
PMID: 39282314
The E3 ubiquitin ligase TRAIP associates with the replisome and helps this molecular machine deal with replication stress. Thus, TRAIP promotes DNA inter-strand crosslink repair by triggering the disassembly of...
4.
Chauhan A, Jhujh S, Stewart G
Biochem J
. 2024 Jul;
481(14):923-944.
PMID: 38985307
Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that damage DNA....
5.
Davies N, Francis T, Oldreive C, Azam M, Wilson J, Byrd P, et al.
Haematologica
. 2024 Jun;
109(12):3989-4006.
PMID: 38841800
Diffuse large B-cell lymphoma (DLBCL) is the most common malignancy that develops in patients with ataxia-telangiectasia, a cancer-predisposing inherited syndrome characterized by inactivating germline ATM mutations. ATM is also frequently...
6.
Stewart G
DNA Repair (Amst)
. 2023 Dec;
134:103616.
PMID: 38159447
For over a decade, it has been known that yeast Sld2, Dpb11, GINS and Polε form the pre-loading complex (pre-LC), which is recruited to a CDC45-bound MCM2-7 complex by the...
7.
Chalabi Hagkarim N, Ip W, Bertzbach L, Abualfaraj T, Dobner T, Molloy D, et al.
Viruses
. 2023 Dec;
15(12).
PMID: 38140597
The adenovirus C5 E1B-55K protein is crucial for viral replication and is expressed early during infection. It can interact with E4orf6 to form a complex that functions as a ubiquitin...
8.
Cvetkovic M, Passaretti P, Butryn A, Reynolds-Winczura A, Kingsley G, Skagia A, et al.
Mol Cell
. 2023 Oct;
83(22):4017-4031.e9.
PMID: 37820732
The MCM motor of the replicative helicase is loaded onto origin DNA as an inactive double hexamer before replication initiation. Recruitment of activators GINS and Cdc45 upon S-phase transition promotes...
9.
Krishnan R, Lapierre M, Gautreau B, Nixon K, El Ghamrasni S, Patel P, et al.
Nucleic Acids Res
. 2023 Sep;
51(19):10484-10505.
PMID: 37697435
Breast cancer linked with BRCA1/2 mutations commonly recur and resist current therapies, including PARP inhibitors. Given the lack of effective targeted therapies for BRCA1-mutant cancers, we sought to identify novel...
10.
Chalabi Hagkarim N, Hajkarim M, Suzuki T, Fujiwara T, Winkler G, Stewart G, et al.
Cells
. 2023 Jul;
12(14).
PMID: 37508532
The mammalian Ccr4-Not complex, carbon catabolite repression 4 (Ccr4)-negative on TATA-less (Not), is a large, highly conserved, multifunctional assembly of proteins that acts at different cellular levels to regulate gene...