A Huwiler
Overview
Explore the profile of A Huwiler including associated specialties, affiliations and a list of published articles.
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53
Citations
748
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Recent Articles
1.
McCracken A, McMonigle R, Tessier J, Fransson R, Perryman M, Chen B, et al.
Leukemia
. 2016 Aug;
31(3):669-677.
PMID: 27573555
The frequency of poor outcomes in relapsed leukemia patients underscores the need for novel therapeutic approaches. The Food and Drug Administration-approved immunosuppressant FTY720 limits leukemia progression by activating protein phosphatase...
2.
Albinet V, Bats M, Huwiler A, Rochaix P, Chevreau C, Segui B, et al.
Oncogene
. 2013 Jul;
33(26):3364-73.
PMID: 23893239
Despite progress in the understanding of the biology and genetics of melanoma, no effective treatment against this cancer is available. The adjacent microenvironment has an important role in melanoma progression....
3.
Koch A, Volzke A, Wunsche C, Meyer zu Heringdorf D, Huwiler A, Pfeilschifter J
Br J Pharmacol
. 2012 Jan;
166(3):1018-32.
PMID: 22221312
Background And Purpose: PPARγ agonists [thiazolidinediones (TZDs)] are known to exert anti-fibrotic effects in the kidney. In addition, we previously demonstrated that sphingosine kinase 1 (SK-1) and intracellular sphingosine-1-phosphate (S1P),...
4.
Schade-Kampmann G, Huwiler A, Hebeisen M, Hessler T, Di Berardino M
Cell Prolif
. 2008 Aug;
41(5):830-40.
PMID: 18673370
Objectives: Many flow-cytometric cell characterization methods require costly markers and colour reagents. We present here a novel device for cell discrimination based on impedance measurement of electrical cell properties in...
5.
Xin C, Ren S, Eberhardt W, Pfeilschifter J, Huwiler A
Br J Pharmacol
. 2007 Feb;
150(7):943-50.
PMID: 17325654
Background And Purpose: FTY720 is a potent immunomodulatory prodrug that is converted to its active phosphorylated form by a sphingosine kinase. Here we have studied whether FTY720 mimicked the action...
6.
Klawitter S, Hofmann L, Pfeilschifter J, Huwiler A
Br J Pharmacol
. 2007 Jan;
150(3):271-80.
PMID: 17200676
Background And Purpose: Extracellular nucleotides act as potent mitogens for renal mesangial cells (MC). In this study we determined whether extracellular nucleotides trigger additional responses in MCs and the mechanisms...
7.
Pfeilschifter J, Eberhardt W, Huwiler A
Eur J Pharmacol
. 2001 Nov;
429(1-3):279-86.
PMID: 11698047
One of the greatest biomedical breakthroughs of the twentieth century was the discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO). NO has received special attention ever...
8.
Franzen R, Pautz A, Brautigam L, Geisslinger G, Pfeilschifter J, Huwiler A
J Biol Chem
. 2001 Jul;
276(38):35382-9.
PMID: 11457826
The lipid signaling molecule ceramide is formed by the action of acid and neutral sphingomyelinases and degraded by acid and neutral ceramidases. Short-term stimulation of mesangial cells with the pro-inflammatory...
9.
Huwiler A, Boddinghaus B, Pautz A, Dorsch S, Franzen R, Briner V, et al.
Biochem Biophys Res Commun
. 2001 Jun;
284(2):404-10.
PMID: 11394893
Recent evidence suggests that the sphingolipid-derived second messenger ceramide and oxidative stress are intimately involved in apoptosis induction. Here we report that exposure of microcapillary glomerular endothelial cells to superoxide-generating...
10.
Huwiler A, Johansen B, Skarstad A, Pfeilschifter J
FASEB J
. 2000 Dec;
15(1):7-9.
PMID: 11099485
Excessive production of eicosanoids is characteristic of many inflammatory diseases. In this study we show that ceramide, which is an early messenger of inflammatory cytokine action, exerts a dual effect...