A Huwiler
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Explore the profile of A Huwiler including associated specialties, affiliations and a list of published articles.
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53
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748
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Recent Articles
11.
Muhl H, Chang J, Huwiler A, Bosmann M, Paulukat J, Ninic R, et al.
Free Radic Biol Med
. 2000 Nov;
29(10):969-80.
PMID: 11084285
Nitric oxide (NO) appears to act as an inflammatory mediator on monocytic cells. Exogenous NO augmented release of chemokines from human promonocytic U937 cells and peripheral blood mononuclear cells. Pharmacological...
12.
Eberhardt W, Huwiler A, Beck K, Walpen S, Pfeilschifter J
J Immunol
. 2000 Nov;
165(10):5788-97.
PMID: 11067938
The modulation of cell signaling by free radicals is important for the pathogenesis of inflammatory diseases. Recently, we have shown that NO reduces IL-1beta-induced matrix metalloproteinase (MMP-9) expression in glomerular...
13.
Huwiler A, Kolter T, Pfeilschifter J, Sandhoff K
Biochim Biophys Acta
. 2000 Jun;
1485(2-3):63-99.
PMID: 10832090
No abstract available.
14.
Huwiler A, Wartmann M, van den Bosch H, Pfeilschifter J
Br J Pharmacol
. 2000 Mar;
129(3):612-8.
PMID: 10711362
1. Extracellular ATP and UTP have been reported to activate a nucleotide receptor (P2Y2-receptor) that mediates arachidonic acid release with subsequent prostaglandin formation, a reaction critically depending on the activity...
15.
Huwiler A, Dorsch S, Briner V, van den Bosch H, Pfeilschifter J
Biochem Biophys Res Commun
. 1999 May;
258(1):60-5.
PMID: 10222235
Exposure of glomerular endothelial cells for 24 h to compounds releasing NO, including spermine-NO, MAHMA-NO, and S-nitroso-glutathione, results in a dose-dependent and delayed (after 24 h) increase in the lipid...
16.
Huwiler A, Pfeilschifter J, van den Bosch H
J Biol Chem
. 1999 Mar;
274(11):7190-5.
PMID: 10066779
Exogenous NO is able to trigger apoptosis of renal mesangial cells, and thus may contribute to acute lytic phases as well as to resolution of glomerulonephritis. However, the mechanism involved...
17.
Huwiler A, Pfeilschifter J
J Exp Biol
. 1999 Feb;
202(Pt 6):655-60.
PMID: 10021319
Nitric oxide (NO) has gained increased attention as a diffusible universal messenger that plays a crucial role in the pathogenesis of inflammatory and autoimmune diseases. Recently, we reported that exogenous...
18.
Beck K, Eberhardt W, Frank S, Huwiler A, Messmer U, Muhl H, et al.
J Exp Biol
. 1999 Feb;
202(Pt 6):645-53.
PMID: 10021318
The discovery of endothelium-derived relaxing factor and its identification as nitric oxide (NO) was one of the most exciting discoveries of biomedical research in the 1980s. Besides its potent vasodilatory...
19.
Kaszkin M, Huwiler A, Scholz K, van den Bosch H, Pfeilschifter J
FEBS Lett
. 1998 Dec;
440(1-2):163-6.
PMID: 9862447
Endogenous ceramide is produced by the action of acidic or neutral sphingomyelinases (SMase) in response to stimuli such as proinflammatory cytokines or other inducers of stress. Interleukin-1beta (IL-1beta) is known...
20.
Lapize C, Pluss C, Werner E, Huwiler A, Pfeilschifter J
Biochem Biophys Res Commun
. 1998 Oct;
251(3):802-5.
PMID: 9790990
GTP cyclohydrolase I is the rate-limiting enzyme in the de novo synthesis pathway of tetrahydrobiopterin which is an essential cofactor for all NO synthase isoforms. The expression of GTP cyclohydrolase...