Sendai Virus-specific T Cell Clones. V. Induction of a Virus-specific Response by Antiidiotypic Antibodies Directed Against a T Helper Cell Clone

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1984 Jun 1

PMID 6327875

Citations 6

Authors

H C Ertl

E Homans

S Tournas

R W Finberg

Affiliations

Soon will be listed here.

Abstract

We used an antiidiotypic antibody directed against a Sendai virus-specific T helper cell clone to stimulate an immune response in vivo. In addition, the antiidiotypic antibody induced T cells that mediated a delayed-type hypersensitivity (DTH) response in several different mouse strains. Induction of the DTH response by the antiidiotypic antibody, in contrast to the DTH responses induced by virus, demonstrated a remarkable lack of H-2 restriction.

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