Induction of Specific Transplantation Immune Reactions Using Anti-idiotypic Antibodies

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1978 Feb 1

PMID 304882

Citations 14

Authors

H Frischknecht

H Binz

H Wigzell

Affiliations

Soon will be listed here.

Abstract

B and T lymphocytes with reactivity against major histocompatibility antigens are known to express this immune potential via a display on the outer surface of antigen-specific, idiotypic receptors. Here, we show that anti-idiotypic antibodies directed against such receptors may serve as specific triggering agents of the idiotype-positive lymphocytes in the physical absence of foreign histocompatibility antigens. This was shown in vitro using normal or immune spleen T cells where anti-idiotypic antibodies would lead to the selective proliferation and development of antigen-specific cytolytic T cells as determined by short-time 51Cr release assays. Furthermore, purified anti-idiotypic antibodies in adjuvant administered in vivo to normal syngeneic animals could be shown to lead to production of high titers of specific alloantibodies. The present experiments were in most cases carried out using auto-anti-idiotypic antibodies as triggering agents. The present results thus lend further support to the concept that idiotype-anti-idiotype reactions may be normal parts of conventional immune processes with either stimulatory or inhibitory consequences, depending upon the prevailing conditions.

Citing Articles

Anti-idiotypes to monoclonal anti-H-2 antibodies. II. Expression of anti-H-2Kk idiotypes on antibodies induced by anti-idiotype or H-2Kk antigen.

Bluestone J, Epstein S, Ozato K, Sharrow S, Sachs D J Exp Med. 1981; 154(5):1305-18.

PMID: 7028910 PMC: 2186503. DOI: 10.1084/jem.154.5.1305.

Suppression of tumor rejection by autologous anti-idiotypic immunity.

Flood P, Kripke M, Rowley D, Schreiber H Proc Natl Acad Sci U S A. 1980; 77(4):2209-13.

PMID: 6966405 PMC: 348682. DOI: 10.1073/pnas.77.4.2209.

Enhancement of the immune response to hepatitis B surface antigen. In vivo administration of antiidiotype induces anti-HBs that expresses a similar idiotype.

Kennedy R, Dreesman G J Exp Med. 1984; 159(3):655-65.

PMID: 6607967 PMC: 2187246. DOI: 10.1084/jem.159.3.655.

Studies on chemically induced tumors in rats: I. Heterogeneity of tumor cells and establishment of syngeneic, tumor-specific cytotoxic T cell clones.

Binz H, Fenner M, Wigzell H Experientia. 1983; 39(1):39-47.

PMID: 6600685 DOI: 10.1007/BF01960619.

Induction of immune responses with anti-idiotypic antibodies: implications for the induction of protective immunity.

Sacks D, Kelsoe G, Sachs D Springer Semin Immunopathol. 1983; 6(1):79-97.

PMID: 6412379 DOI: 10.1007/BF01857368.

References

Barcinski M, Rosenthal A . Immune response gene control of determinant selection. I. Intramolecular mapping of the immunogenic sites on insulin recognized by guinea pig T and B cells. J Exp Med. 1977; 145(3):726-42. PMC: 2180714. DOI: 10.1084/jem.145.3.726. View

Aguet M, Andersson L, Andersson R, Wight E, Binz H, Wigzell H . Induction of specific immune unresponsiveness with purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. II. An analysis of the effects measured at the cellular and serological levels. J Exp Med. 1978; 147(1):50-61. PMC: 2184098. DOI: 10.1084/jem.147.1.50. View

Wight E, Binz H . Specific suppression of MLC and CML by anti-idiotypic antibodies in the mouse. Scand J Immunol. 1977; 6(9):959-65. DOI: 10.1111/j.1365-3083.1977.tb00417.x. View

Rajewsky K, Eichmann K . Antigen receptors of T helper cells. Contemp Top Immunobiol. 1977; 7:69-112. DOI: 10.1007/978-1-4684-3054-7_3. View

Binz H, Wigzell H . Antigen-binding, idiotypic T-lymphocyte receptors. Contemp Top Immunobiol. 1977; 7:113-77. DOI: 10.1007/978-1-4684-3054-7_4. View

Braun M, Saal F . The T-cell receptor and cytotoxicity An anti=idiotype antiserum that inhibits a graft-versus-host reaction does not inhibit cell-mediated cytotoxicity. Cell Immunol. 1977; 30(2):254-60. DOI: 10.1016/0008-8749(77)90069-7. View

Binz H, Wigzell H . Specific transplantation tolerance induced by autoimmunization against the individual's own, naturally occurring idiotypic, antigen-binding receptors. J Exp Med. 1976; 144(6):1438-57. PMC: 2190473. DOI: 10.1084/jem.144.6.1438. View

Binz H, Wigzell H, Bazin H . T-cell idiotypes are linked to immunoglobulin heavy chain genes. Nature. 1976; 264(5587):639-42. DOI: 10.1038/264639a0. View

Paul W, Benacerraf B . Functional specificity of thymus- dependent lymphocytes. Science. 1977; 195(4284):1293-300. DOI: 10.1126/science.320663. View

10.

Falkoff R, Dutton R . Evidence that Con A induces cytotoxicity in the same subclass of T cells as does alloimmunization. J Immunol. 1977; 118(5):1600-6. View

11.

Andersson L, Aguet M, Wight E, Andersson R, Binz H, Wigzell H . Induction of specific immune unresponsiveness using purified mixed leukocyte culture-activated T lymphoblasts as autoimmunogen. I. Demonstration of general validity as to species and histocompatibility barriers. J Exp Med. 1977; 146(4):1124-37. PMC: 2180818. DOI: 10.1084/jem.146.4.1124. View

12.

Anderson L, Binz H, Wigzell H . Specific unresponsiveness to transplantation antigens induced by auto-immunisation with syngeneic, antigen-specific T lymphoblasts. Nature. 1976; 264(5588):778-80. DOI: 10.1038/264778a0. View

13.

Howard J, Wilson D . Specific positive selection of lymphocytes reactive to strong histocompatibility antigens. J Exp Med. 1974; 140(3):660-72. PMC: 2139612. DOI: 10.1084/jem.140.3.660. View

14.

Coutinho A, Moller G . Editorial: Immune activation of B cells: evidence for 'one nonspecific triggering signal' not delivered by the Ig receptors. Scand J Immunol. 1974; 3(2):133-46. View

15.

Sell S . Development of restrictions in the expression of immunoglobulin specificities by lymphoid cells. Transplant Rev. 1970; 5:19-44. DOI: 10.1111/j.1600-065x.1970.tb00355.x. View

16.

Binz H, Wigzell H . Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. II. Determination of frequency and characteristics of idiotypic T and B lymphocytes in normal rats using direct visualization. J Exp Med. 1975; 142(5):1218-30. PMC: 2189962. DOI: 10.1084/jem.142.5.1218. View

17.

Trenkner E, Riblet R . Induction of antiphosphorylcholine antibody formation by anti-idiotypic antibodies. J Exp Med. 1975; 142(5):1121-32. PMC: 2189971. DOI: 10.1084/jem.142.5.1121. View

18.

Hammerling G, Black S, Berek C, Eichmann K, Rajewsky K . Idiotypic analysis of lymphocytes in vitro. II. Genetic control of T-helper cell responsiveness to anti-idiotypic antibody. J Exp Med. 1976; 143(4):861-9. PMC: 2190172. DOI: 10.1084/jem.143.4.861. View

19.

Binz H, Wigzell H . Shared idiotypic determinants on B and T lymphocytes reactive against the same antigenic determinants. I. Demonstration of similar or identical idiotypes on IgG molecules and T-cell receptors with specificity for the same alloantigens. J Exp Med. 1975; 142(1):197-211. PMC: 2189868. DOI: 10.1084/jem.142.1.197. View

20.

Click R, Benck L, Alter B . Immune responses in vitro. I. Culture conditions for antibody synthesis. Cell Immunol. 1972; 3(2):264-76. DOI: 10.1016/0008-8749(72)90165-7. View