Antigen-specific T-cell Factors in the Genetic Control of the Immune Response to Poly(Tyr,Glu)-polyDLAla--polyLys. Evidence for T- and B-cell Defects in SJL Mice

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1975 Mar 1

PMID 46918

Citations 16

Authors

E Mozes

R Isac

M J Taussig

Affiliations

Soon will be listed here.

Abstract

The cellular basis of the genetic control of the immune response to poly(LTyr, LGlu)-polyDLAla--polyLLys [(T,G)-A--L] in SJL (H-2s, low responder) mice has been investigated using T-cell factors. Thymocytes of SJL origin were educated to (T,G)-A--L and tested for their ability to produce an antigen-specific factor capable of cooperating in vivo with bone marrow cells of either SJL or C3H.SW (high responder) origin. SJL T cells were found to be incapable of producing such a cooperative factor, in contrast with results previously obtained with C3H/HeJ (low responders) and C3H.SW strains. Moreover, SJL bone marrow cells did not produce an antibody response to (T,G)-A--L, even when combined with factor produced by high responder (C3H.SW) mice. Thus, both T and B cells appear to be defective in the SJL strain in the response to (T,G)-A--L.

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Genetic regulation of delayed-type hypersensitivity responses to poly (Tyr,Glu)-poly(DLAla)--poly(Lys): expression of the genetic defect in the induction and manifestation phases in H-2s and H-2f mice.

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Genetic regulation of delayed-type hypersensitivity responses to poly(LTyr,LGu)-poly(DLAla)--poly(LLys). I. Expression of the genetic defect at two phases of the immune process.

STRASSMANN G, Eshhar Z, Mozes E J Exp Med. 1980; 151(2):265-74.

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Immune response potential to poly(Tyr,Glu)-poly(DLAla)--poly(Lys) of human T cells of different donors.

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