Antigen-specific T-cell Factor in Cell Cooperation: Physical Properties and Mapping in the Left-hand (K) Half of H-2

Overview

Journal J Exp Med

Specialties Allergy & Immunology
General Medicine

Date 1974 Dec 1

PMID 4610078

Citations 29

Authors

A J Munro

M J Taussig

R Campbell

H Williams

Y Lawson

Affiliations

Soon will be listed here.

Abstract

Mouse thymus cells, educated to poly(tyrosyl,glutamyl)-polyDLalanyl--polylysyl [(T,G)-A--L], release an antigen-specific factor on brief culture in vitro. The factor cooperates with bone marrow cells in the antibody response to (T,G)-A--L in irradiated recipients. Its mol wt determined from Sephadex G100 chromatography is in the region of 50,000. The factor is removed by specific antigen-coated columns, but not by anti-immunoglobulin (anti-Fab, anti-micro, anti-Fv) adsorbents. The factor is removed by alloantisera directed against the H-2 haplotype of the strain in which it is produced. Moreover, only antisera with specificity for the K side of H-2 were successful in removing the factor activity.

Citing Articles

Partial characterization of murine and monkey helper factor to a streptococcal antigen.

Zanders E, Lamb J, Kontiainen S, Lehner T Immunology. 1980; 41(3):587-96.

PMID: 7007212 PMC: 1458155.

Helper and suppressor T cell factors.

Germain R, Benacerraf B Springer Semin Immunopathol. 1980; 3(1):93-127.

PMID: 6792727 DOI: 10.1007/BF00199927.

Antigen-specific T-cell factors.

Taussig M Immunology. 1980; 41(4):759-87.

PMID: 6161877 PMC: 1458315. DOI: 10.1007/BF00199524.

Antigen specific T cell factors.

Feldmann M, Kontiainen S Mol Cell Biochem. 1980; 30(3):177-93.

PMID: 6157084 DOI: 10.1007/BF00230172.

Activation of T and B lymphocytes in vitro. III. Presence of Ia determinants on allogeneic effect factor.

Armerding D, Sachs D, Katz D J Exp Med. 1974; 140(6):1717-22.

PMID: 4139236 PMC: 2139747. DOI: 10.1084/jem.140.6.1717.

References

Jerne N, Nordin A . Plaque Formation in Agar by Single Antibody-Producing Cells. Science. 1963; 140(3565):405. DOI: 10.1126/science.140.3565.405. View

Hammerling G, McDevitt H . Antigen binding T and B lymphocytes. II. Studies on the inhibition of antigen binding to T and B cells by anti-immunoglobulin and anti-H-2 sera. J Immunol. 1974; 112(5):1734-40. View

Taussig M . T cell factor which can replace T cells in vivo. Nature. 1974; 248(445):234-6. DOI: 10.1038/248234a0. View

Katz D . The allogeneic effect on immune responses: model for regulatory influences of T lymphocytes on the immune system. Transplant Rev. 1972; 12:141-79. DOI: 10.1111/j.1600-065x.1972.tb00055.x. View

Jaton J, Sela M . Role of optical configuration in the immunogenicity and specificity of synthetic antigens derived from multichain polyproline. J Biol Chem. 1968; 243(21):5616-26. View

Taussig J, Mozes E, Isac R . Antigen-specific thymus cell factors in the genetic control of the immune response to poly-(tyrosyl, glutamyl)-poly-D, L-alanyl--poly-lysyl. J Exp Med. 1974; 140(2):301-12. PMC: 2139587. DOI: 10.1084/jem.140.2.301. View

Marchalonis J, Cone R, Atwell J . Isolation and partial characterization of lymphocyte surface immunoglobulins. J Exp Med. 1972; 135(4):956-71. PMC: 2139144. DOI: 10.1084/jem.135.4.956. View

Roelants G, Forni L, Pernis B . Blocking and redistribution ("capping") of antigen receptors on T and B lymphocytes by anti-immunoglobulin antibody. J Exp Med. 1973; 137(4):1060-77. PMC: 2139224. DOI: 10.1084/jem.137.4.1060. View

Sela M, Fuchs S, Arnon R . Studies on the chemical basis of the antigenicity of proteins. 5. Synthesis, characterization and immunogenicity of some multichain and linear polypeptides containing tyrosine. Biochem J. 1962; 85:223-35. PMC: 1243934. DOI: 10.1042/bj0850223. View

10.

Hammerling U, Rajewsky K . Evidence for surface-associated immunoglobulin on T and B lymphocytes. Eur J Immunol. 1971; 1(6):447-52. DOI: 10.1002/eji.1830010608. View

11.

Waldmann H, Munro A . Letter: T cell-dependent mediator in the immune response. Nature. 1973; 243(5406):356-7. DOI: 10.1038/243356a0. View

12.

Schimpl A, WECKER E . Replacement of T-cell function by a T-cell product. Nat New Biol. 1972; 237(70):15-7. DOI: 10.1038/newbio237015a0. View

13.

Amos H, LACHMANN P . The immunological specificity of a macrophage inhibition factor. Immunology. 1970; 18(2):269-78. PMC: 1455541. View

14.

Basten A, Miller J, Warner N, Pye J . Specific inactivation of thymus-derived (T) and non-thymus-derived (B) lymphocytes by 125I-labelled antigen. Nat New Biol. 1971; 231(21):104-6. DOI: 10.1038/newbio231104a0. View

15.

Evans R, Grant C, Cox H, Steele K, Alexander P . Thymus-derived lymphocytes produce an immunologically specific macrophage-arming factor. J Exp Med. 1972; 136(5):1318-22. PMC: 2139296. DOI: 10.1084/jem.136.5.1318. View

16.

Shevach E, Paul W, Green I . Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera. J Exp Med. 1972; 136(5):1207-21. PMC: 2139300. DOI: 10.1084/jem.136.5.1207. View

17.

Inbar D, Hochman J, Givol D . Localization of antibody-combining sites within the variable portions of heavy and light chains. Proc Natl Acad Sci U S A. 1972; 69(9):2659-62. PMC: 427010. DOI: 10.1073/pnas.69.9.2659. View

18.

Shevach E, Green I, Paul W . Alloantiserum-induced inhibition of immune response gene product function. II. Genetic analysis of target antigens. J Exp Med. 1974; 139(3):679-95. PMC: 2139552. DOI: 10.1084/jem.139.3.679. View

19.

Hunt S, Williams A . The origin of cell surface immunoglobulin of marrow-derived and thymus-derived lymphocytes of the rat. J Exp Med. 1974; 139(3):479-96. PMC: 2139542. DOI: 10.1084/jem.139.3.479. View

20.

Benacerraf B, McDevitt H . Histocompatibility-linked immune response genes. Science. 1972; 175(4019):273-9. DOI: 10.1126/science.175.4019.273. View