In Vitro Studies on H-2 Linked Unresponsiveness. 1. Normal Helper Cells to (T,G)-A-L and GAT in Low and Non-responder Mice

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 1977 Mar 1

PMID 66198

Citations 8

Authors

S Howie

M Feldmann

E Mozes

P H Maurer

Affiliations

Soon will be listed here.

Abstract

Lymphoid cells from unprimed high responder (C57BL/10) and low responder mice (B10.Br, B10.A, CBA) to (T,G)-A-L and high responder (B10, B10.A) and non-responder (B10.G, DBA/I) mice to GAT can be induced to form antigen specific T-helper cells in vitro under identical culture conditions. The helper cells induced from high and low or non-responder mice appear to be identical in efficiency, antigen concentration requirement for induction and induction kinetics.

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