Unlocking the Secrets of Mitochondria in the Cardiovascular System: Path to a Cure in Heart Failure—A Report from the 2018 National Heart, Lung, and Blood Institute Workshop

Overview

Journal Circulation

Specialty Cardiology & Vascular Diseases

Date 2019 Nov 27

PMID 31769940

Citations 67

Authors

Rong Tian

Wilson S Colucci

Zoltan Arany

Markus M Bachschmid

Scott W Ballinger

Sihem Boudina

James E Bruce

David W Busija

Sergey Dikalov

Gerald W Dorn Ii

Zorina S Galis

Roberta A Gottlieb

Daniel P Kelly

Richard N Kitsis

Mark J Kohr

Daniel Levy

E Douglas Lewandowski

Joseph M McClung

Daria Mochly-Rosen

Kevin D OBrien

Brian ORourke

Joon-Young Park

Peipei Ping

Michael N Sack

Shey-Shing Sheu

Yang Shi

Sruti Shiva

Douglas C Wallace

Robert G Weiss

Hilary J Vernon

Renee Wong

Lisa Schwartz Longacre

Affiliations

Soon will be listed here.

Abstract

Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction. The National Heart, Lung, and Blood Institute convened a group of leading experts in heart failure, cardiovascular diseases, and mitochondria research in August 2018. These experts reviewed the current state of science and identified key gaps and opportunities in basic, translational, and clinical research focusing on the potential of mitochondria-based therapeutic strategies in heart failure. The workshop provided short- and long-term recommendations for moving the field toward clinical strategies for the prevention and treatment of heart failure and cardiovascular diseases by using mitochondria-based approaches.

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