Wilson S Colucci
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Explore the profile of Wilson S Colucci including associated specialties, affiliations and a list of published articles.
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113
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6060
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Recent Articles
1.
Croteau D, Baka T, Young S, He H, Chambers J, Qin F, et al.
Biomed Pharmacother
. 2023 Feb;
160:114310.
PMID: 36731341
Background: Elevated myocardial intracellular sodium ([Na]) was shown to decrease mitochondrial calcium ([Ca]) via mitochondrial sodium/calcium exchanger (NCX), resulting in decreased mitochondrial ATP synthesis. The sodium-glucose co-transporter 2 inhibitor (SGLT2i)...
2.
Croteau D, Luptak I, Chambers J, Hobai I, Panagia M, Pimentel D, et al.
J Am Heart Assoc
. 2021 Jun;
10(13):e019995.
PMID: 34169737
Background Inhibitors of the sodium-glucose linked transporter 2 improve cardiovascular outcomes in patients with or without type 2 diabetes mellitus, but the effects on cardiac energetics and mitochondrial function are...
3.
Goodman J, Qin F, Morgan R, Chambers J, Croteau D, Siwik D, et al.
Circulation
. 2020 Oct;
142(25):2459-2469.
PMID: 33076678
Background: SERCA [sarco(endo)plasmic reticulum calcium ATPase] is regulated by oxidative posttranslational modifications at cysteine 674 (C674). Because sarcoplasmic reticulum (SR) calcium has been shown to play a critical role in...
4.
Croteau D, Qin F, Chambers J, Kallick E, Luptak I, Panagia M, et al.
JACC Basic Transl Sci
. 2020 Oct;
5(9):916-927.
PMID: 33015414
Mice with obesity and metabolic heart disease (MHD) due to a high-fat, high-sucrose diet were treated with placebo, a clinically relevant dose of sacubitril (SAC)/valsartan (VAL), or an equivalent dose...
5.
Panagia M, Yang J, Gale E, Wang H, Luptak I, Chen H, et al.
Sci Rep
. 2020 Jul;
10(1):11209.
PMID: 32641756
Multiplexed imaging is essential for the evaluation of substrate utilization in metabolically active organs, such as the heart and brown adipose tissue (BAT), where substrate preference changes in pathophysiologic states....
6.
Panagia M, He H, Baka T, Pimentel D, Croteau D, Bachschmid M, et al.
NMR Biomed
. 2020 Feb;
33(5):e4258.
PMID: 32066202
Metabolic heart disease (MHD), which is strongly associated with heart failure with preserved ejection fraction, is characterized by reduced mitochondrial energy production and contractile performance. In this study, we tested...
7.
Tian R, Colucci W, Arany Z, Bachschmid M, Ballinger S, Boudina S, et al.
Circulation
. 2019 Nov;
140(14):1205-1216.
PMID: 31769940
Mitochondria have emerged as a central factor in the pathogenesis and progression of heart failure, and other cardiovascular diseases, as well, but no therapies are available to treat mitochondrial dysfunction....
8.
Luptak I, Morgan R, Baka T, Croteau D, Moverman D, Sarnak H, et al.
Int J Biochem Cell Biol
. 2019 Jul;
114:105569.
PMID: 31299273
Calcium (Ca), an important second messenger, regulates many cellular activities and varies spatiotemporally within the cell. Conventional methods to monitor Ca changes, such as synthetic Ca indicators, are not targetable,...
9.
Luptak I, Qin F, Sverdlov A, Pimentel D, Panagia M, Croteau D, et al.
Antioxid Redox Signal
. 2019 May;
31(7):539-549.
PMID: 31088291
Metabolic syndrome is associated with metabolic heart disease (MHD) that is characterized by left ventricular (LV) hypertrophy, interstitial fibrosis, contractile dysfunction, and mitochondrial dysfunction. Overexpression of catalase in mitochondria (transgenic...
10.
Gopal D, Ayalon N, Wang Y, Siwik D, Sverdlov A, Donohue C, et al.
J Am Heart Assoc
. 2019 Apr;
8(7):e011100.
PMID: 30929550
Background Obesity is a precursor to heart failure with preserved ejection fraction. Biomarkers that identify preclinical metabolic heart disease ( MHD ) in young obese patients would help identify high-risk...