Douglas C Wallace
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Explore the profile of Douglas C Wallace including associated specialties, affiliations and a list of published articles.
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232
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Recent Articles
1.
Ai C, Li H, Wang C, Ji Y, Wallace D, Qian J, et al.
JCI Insight
. 2025 Mar;
PMID: 40036074
Leber hereditary optic neuropathy (LHON) is a paradigm for mitochondrial retinopathy due to mitochondrial DNA (mtDNA) mutations. However, the mechanism underlying retinal cell-specific effects of LHON-linked mtDNA mutations remains poorly...
2.
Stojanovic L, Abbotts R, Tripathi K, Coon C, Rajendran S, Abbasi Farid E, et al.
Cancer Res
. 2025 Jan;
PMID: 39804147
DNA methyltransferase and poly (ADP-ribose) polymerase inhibitors (DNMTis, PARPis) induce a stimulator of interferon genes (STING)-dependent pathogen mimicry response (PMR) in ovarian and other cancers. Here, we showed that combining...
3.
Yardeni T, Olali A, Chen H, Wang L, Halton J, Zenab A, et al.
Proc Natl Acad Sci U S A
. 2025 Jan;
122(1):e2417252121.
PMID: 39752523
Mitochondrial DNA (mtDNA) is highly polymorphic, and host mtDNA variation has been associated with altered cancer severity. To determine the basis of this mtDNA-cancer association, we analyzed conplastic mice with...
4.
Khan M, Farooqi S, Mitchell K, Chowdhury S, Cabrera-Ayala M, Huang J, et al.
FASEB J
. 2024 Dec;
38(23):e70228.
PMID: 39641547
Sodium butyrate can reduce inflammation, but it is not known if butyrate can improve mitochondrial dysfunction during sepsis. We tested butyrate to prevent or reverse lipopolysaccharide (LPS)-induced mitochondrial dysfunction in...
5.
Topper M, Guarnieri J, Haltom J, Chadburn A, Cope H, Frere J, et al.
Proc Natl Acad Sci U S A
. 2024 Nov;
121(49):e2401968121.
PMID: 39602262
Lethal COVID-19 outcomes are attributed to classic cytokine storm. We revisit this using RNA sequencing of nasopharyngeal and 40 autopsy samples from patients dying of SARS-CoV-2. Subsets of the 100...
6.
Guarnieri J, Kim J, Wallace D, Mason C, Muratani M, Beheshti A
Methods Mol Biol
. 2024 Nov;
2878():273-291.
PMID: 39546268
To be able to understand how spaceflight can affect human biology, there is a need for maximizing the amount of information that can be obtained from experiments flown to space....
7.
Stojanovic L, Abbotts R, Tripathi K, Coon C, Rajendran S, Abbasi Farid E, et al.
bioRxiv
. 2024 Nov;
PMID: 39484607
DNA methyltransferase and poly(ADP-ribose) polymerase inhibitors (DNMTis, PARPis) induce a stimulator of interferon (IFN) genes (STING)-dependent pathogen mimicry response (PMR) in ovarian (OC) and other cancers. We now show that...
8.
Zhu Y, Kohli N, Young A, Sheldon M, Coni J, Rajasekaran M, et al.
Antioxidants (Basel)
. 2024 Oct;
13(10).
PMID: 39456479
Although the precise molecular mechanisms responsible for neuronal death and motor dysfunction in late-onset Parkinson's disease (PD) are unknown, evidence suggests that mitochondrial dysfunction and neuroinflammation occur early, leading to...
9.
Lee C, Wallace D, Burke P
Mitochondrial Commun
. 2024 Oct;
2:38-47.
PMID: 39449993
Photobleaching and phototoxicity can induce detrimental effects on cell viability and compromise the integrity of collected data, particularly in studies utilizing super-resolution microscopes. Given the involvement of multiple factors, it...
10.
Galeano D, Imrat , Haltom J, Andolino C, Yousey A, Zaksas V, et al.
Nat Commun
. 2024 Oct;
15(1):9149.
PMID: 39443444
MicroRNAs (miRNAs) have been implicated in human disorders, from cancers to infectious diseases. Targeting miRNAs or their target genes with small molecules offers opportunities to modulate dysregulated cellular processes linked...