Brian ORourke
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Explore the profile of Brian ORourke including associated specialties, affiliations and a list of published articles.
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215
Citations
8871
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Recent Articles
1.
Sedighi S, Liu T, OMeally R, Cole R, ORourke B, Foster D
bioRxiv
. 2024 Nov;
PMID: 39605458
Heart failure (HF) is a complex condition characterized by the inability of the heart to pump sufficient oxygen to the organs to meet their metabolic needs. Among the altered signal...
2.
Quiroga D, Roman B, Salih M, Daccarett-Bojanini W, Garbus H, Ebenebe O, et al.
J Mol Cell Cardiol
. 2024 Jun;
194:59-69.
PMID: 38880194
Obesity-induced cardiac dysfunction is growing at an alarming rate, showing a dramatic increase in global prevalence. Mitochondrial translocation of miR-181c in cardiomyocytes results in excessive reactive oxygen species (ROS) production...
3.
Radu P, Kumar G, Cole A, Fameli A, Guthrie M, Annemans L, et al.
Oncologist
. 2024 Apr;
29(6):465-472.
PMID: 38630538
Background: Genomic and molecular alterations are increasingly important in cancer diagnosis, and scientific advances are opening new treatment avenues. Precision oncology (PO) uses a patient's genomic profile to determine optimal...
4.
Ashok D, Liu T, Criscione J, Prakash M, Kim B, Chow J, et al.
bioRxiv
. 2024 Jan;
PMID: 38260287
Background: Cardiac risk rises during acute SARS-CoV-2 infection and in long COVID syndrome in humans, but the mechanisms behind COVID-19-linked arrhythmias are unknown. This study explores the acute and long...
5.
Pearah A, Ramatchandirin B, Liu T, Wolf R, Ikeda A, Radovick S, et al.
Cell Chem Biol
. 2023 Oct;
30(12):1585-1600.e6.
PMID: 37890479
Impaired mitochondrial dynamics causes aging-related or metabolic diseases. Yet, the molecular mechanism responsible for the impairment of mitochondrial dynamics is still not well understood. Here, we report that elevated blood...
6.
Wang J, Papanicolaou K, Tryon R, Sangalang J, Salazar B, Suarez-Pierre A, et al.
JTCVS Open
. 2023 Oct;
15:231-241.
PMID: 37808059
Objective: The adenosine triphosphate-sensitive potassium channel opener diazoxide mimics ischemic preconditioning and is cardioprotective. Clarification of diazoxide's site and mechanism of action could lead to targeted pharmacologic therapies for patients...
7.
Cosarderelioglu C, Kreimer S, Plaza-Rodriguez A, Iglesias P, Talbot Jr C, Siragy H, et al.
J Am Heart Assoc
. 2023 Sep;
12(18):e030791.
PMID: 37681524
Background The renin-angiotensin system plays a crucial role in human physiology, and its main hormone, angiotensin, activates 2 G-protein-coupled receptors, the angiotensin type-1 and type-2 receptors, in almost every organ....
8.
Velmurugan S, Liu T, Chen K, Despa F, ORourke B, Despa S
J Am Heart Assoc
. 2023 Jul;
12(14):e029997.
PMID: 37421267
Background Mitochondrial dysfunction contributes to the cardiac remodeling triggered by type 2 diabetes (T2D). Mitochondrial Ca concentration ([Ca]) modulates the oxidative state and cytosolic Ca regulation. Thus, we investigated how...
9.
Ashok D, Papanicolaou K, Sidor A, Wang M, Solhjoo S, Liu T, et al.
J Biol Chem
. 2023 Apr;
299(6):104708.
PMID: 37061004
Physiologic Ca entry via the Mitochondrial Calcium Uniporter (MCU) participates in energetic adaption to workload but may also contribute to cell death during ischemia/reperfusion (I/R) injury. The MCU has been...
10.
Kurz F, Aon M, Schlemmer H, Jende J, ORourke B, Armoundas A
Biophys J
. 2023 Mar;
122(8):1459-1469.
PMID: 36905121
Mitochondrial inner membrane potentials in cardiomyocytes may oscillate in cycles of depolarization/repolarization when the mitochondrial network is exposed to metabolic or oxidative stress. The frequencies of such oscillations are dynamically...