LncRNA PVT1 As an Effective Biomarker for Cancer Diagnosis and Detection Based on Transcriptome Data and Meta-analysis

Overview

Journal Oncotarget

Specialty Oncology

Date 2017 Nov 2

PMID 29088881

Citations 15

Authors

Yunhong Zeng

Tieqiang Wang

Yi Liu

Zhan Su

Pingtao Lu

Xiaoliang Chen

Dongsheng Hu

Affiliations

Soon will be listed here.

Abstract

Purpose: Long noncoding RNA (lncRNA) PVT1 was detected all types of cancer from Cancer Genome Atlas (TCGA) project; however, the role of PVT1 in cancer is not clear. This study aimed to reanalyze and determine the effect of PVT1 on cancer diagnosis, especially detection in serum.

Materials And Methods: Differential expression of PVT1 between cancers and corresponding normal tissues and receiver operating characteristic (ROC) curve were analyzed for all types of cancers in TCGA database. RevMan5.3, Meta-DiSc1.4 and STATA14.0 were used to estimate pooled diagnostic effects of PVT1 in tissue as well as serum.

Results: Compared to corresponding normal tissues, PVT1 expression was significantly upregulated in 18 types of cancer and further being an effective diagnosis biomarker in 16 of them. For the 23 diagnosis tests performed in tissue, the pooled AUC and diagnostic odd ratio (DOR) were estimated to be 0.81 (95% CI: 0.76-0.86) and 17.25 (95% CI: 8.43-35.27), when the pooled AUC and DOR were 0.83 (95%CI: 0.75-0.91) and 13.86 (95% CI: 4.70-40.66) for serum tests. Furthermore, the pooled sensitivity and specificity were 0.83 (95% CI: 0.76-0.89) and 0.74 (95% CI:0.70-0.84) for tissue as well as 0.81 (95% CI: 0.76-0.86) and 0.76 (95% CI:0.70-0.81) for serum.

Conclusions: PVT1, especially in serum, might be a usable biomarker for cancer diagnosis / detection.

Citing Articles

Noncoding RNA PVT1 in osteosarcoma: The roles of lncRNA PVT1 and circPVT1.

Wu T, Ji Z, Lin H, Wei B, Xie G, Ji G Cell Death Discov. 2022; 8(1):456.

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The Effect of lncRNA-PVT1 on Liver Cancer Rats by Regulating the Expression of MMP9.

Lu B, Cheng M, Wang T Biomed Res Int. 2022; 2022:4126839.

PMID: 36164442 PMC: 9509214. DOI: 10.1155/2022/4126839.

Competitive endogenous RNA network identifies four long non-coding RNA signature as a candidate prognostic biomarker for lung adenocarcinoma.

Hu J, Wang T, Chen Q Transl Cancer Res. 2022; 8(4):1046-1064.

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Long Non-Coding RNAs in Diagnosis, Treatment, Prognosis, and Progression of Glioma: A State-of-the-Art Review.

Momtazmanesh S, Rezaei N Front Oncol. 2021; 11:712786.

PMID: 34322395 PMC: 8311560. DOI: 10.3389/fonc.2021.712786.

Association of MALAT1 and PVT1 Variants, Expression Profiles and Target miRNA-101 and miRNA-186 with Colorectal Cancer: Correlation with Epithelial-Mesenchymal Transition.

Radwan A, Shaker O, El-Boghdady N, Senousy M Int J Mol Sci. 2021; 22(11).

PMID: 34200314 PMC: 8201273. DOI: 10.3390/ijms22116147.

References

Fagan T . Letter: Nomogram for Bayes's theorem. N Engl J Med. 1975; 293(5):257. DOI: 10.1056/NEJM197507312930513. View

Glas A, Lijmer J, Prins M, Bonsel G, Bossuyt P . The diagnostic odds ratio: a single indicator of test performance. J Clin Epidemiol. 2003; 56(11):1129-35. DOI: 10.1016/s0895-4356(03)00177-x. View

Walter S . The partial area under the summary ROC curve. Stat Med. 2005; 24(13):2025-40. DOI: 10.1002/sim.2103. View

Deeks J, Macaskill P, Irwig L . The performance of tests of publication bias and other sample size effects in systematic reviews of diagnostic test accuracy was assessed. J Clin Epidemiol. 2005; 58(9):882-93. DOI: 10.1016/j.jclinepi.2005.01.016. View

Zamora J, Abraira V, Muriel A, Khan K, Coomarasamy A . Meta-DiSc: a software for meta-analysis of test accuracy data. BMC Med Res Methodol. 2006; 6:31. PMC: 1552081. DOI: 10.1186/1471-2288-6-31. View

Tsai M, Manor O, Wan Y, Mosammaparast N, Wang J, Lan F . Long noncoding RNA as modular scaffold of histone modification complexes. Science. 2010; 329(5992):689-93. PMC: 2967777. DOI: 10.1126/science.1192002. View

Guttman M, Rinn J . Modular regulatory principles of large non-coding RNAs. Nature. 2012; 482(7385):339-46. PMC: 4197003. DOI: 10.1038/nature10887. View

Chen D, Wang Y, Chuai Z, Huang J, Wang Y, Liu K . High-resolution melting analysis for accurate detection of BRAF mutations: a systematic review and meta-analysis. Sci Rep. 2014; 4:4168. PMC: 3933866. DOI: 10.1038/srep04168. View

Riquelme E, Suraokar M, Rodriguez J, Mino B, Lin H, Rice D . Frequent coamplification and cooperation between C-MYC and PVT1 oncogenes promote malignant pleural mesothelioma. J Thorac Oncol. 2014; 9(7):998-1007. PMC: 4287384. DOI: 10.1097/JTO.0000000000000202. View

10.

Wang F, Yuan J, Wang S, Yang F, Yuan S, Ye C . Oncofetal long noncoding RNA PVT1 promotes proliferation and stem cell-like property of hepatocellular carcinoma cells by stabilizing NOP2. Hepatology. 2014; 60(4):1278-90. DOI: 10.1002/hep.27239. View

11.

Ding C, Yang Z, Lv Z, Du C, Xiao H, Peng C . Long non-coding RNA PVT1 is associated with tumor progression and predicts recurrence in hepatocellular carcinoma patients. Oncol Lett. 2015; 9(2):955-963. PMC: 4301564. DOI: 10.3892/ol.2014.2730. View

12.

Tomczak K, Czerwinska P, Wiznerowicz M . The Cancer Genome Atlas (TCGA): an immeasurable source of knowledge. Contemp Oncol (Pozn). 2015; 19(1A):A68-77. PMC: 4322527. DOI: 10.5114/wo.2014.47136. View

13.

Colombo T, Farina L, Macino G, Paci P . PVT1: a rising star among oncogenic long noncoding RNAs. Biomed Res Int. 2015; 2015:304208. PMC: 4391155. DOI: 10.1155/2015/304208. View

14.

Kong R, Zhang E, Yin D, You L, Xu T, Chen W . Long noncoding RNA PVT1 indicates a poor prognosis of gastric cancer and promotes cell proliferation through epigenetically regulating p15 and p16. Mol Cancer. 2015; 14:82. PMC: 4399399. DOI: 10.1186/s12943-015-0355-8. View

15.

Yu X, Li Z . Long non-coding RNA HOTAIR: A novel oncogene (Review). Mol Med Rep. 2015; 12(4):5611-8. DOI: 10.3892/mmr.2015.4161. View

16.

Zhou Q, Chen J, Feng J, Wang J . Long noncoding RNA PVT1 modulates thyroid cancer cell proliferation by recruiting EZH2 and regulating thyroid-stimulating hormone receptor (TSHR). Tumour Biol. 2015; 37(3):3105-13. DOI: 10.1007/s13277-015-4149-9. View

17.

Cui D, Yu C, Liu M, Xia Q, Zhang Y, Jiang W . Long non-coding RNA PVT1 as a novel biomarker for diagnosis and prognosis of non-small cell lung cancer. Tumour Biol. 2015; 37(3):4127-34. DOI: 10.1007/s13277-015-4261-x. View

18.

Raveh E, Matouk I, Gilon M, Hochberg A . The H19 Long non-coding RNA in cancer initiation, progression and metastasis - a proposed unifying theory. Mol Cancer. 2015; 14:184. PMC: 4632688. DOI: 10.1186/s12943-015-0458-2. View

19.

Lee J, Kim K, Choi S, Huh J, Park S . Systematic Review and Meta-Analysis of Studies Evaluating Diagnostic Test Accuracy: A Practical Review for Clinical Researchers-Part II. Statistical Methods of Meta-Analysis. Korean J Radiol. 2015; 16(6):1188-96. PMC: 4644739. DOI: 10.3348/kjr.2015.16.6.1188. View

20.

Gao J, Cao R, Mu H . Long non-coding RNA UCA1 may be a novel diagnostic and predictive biomarker in plasma for early gastric cancer. Int J Clin Exp Pathol. 2016; 8(10):12936-42. PMC: 4680432. View