Modular Regulatory Principles of Large Non-coding RNAs

Overview

Journal Nature

Specialty Science

Date 2012 Feb 17

PMID 22337053

Citations 1235

Authors

Mitchell Guttman

John L Rinn

Affiliations

Soon will be listed here.

Abstract

It is clear that RNA has a diverse set of functions and is more than just a messenger between gene and protein. The mammalian genome is extensively transcribed, giving rise to thousands of non-coding transcripts. Whether all of these transcripts are functional is debated, but it is evident that there are many functional large non-coding RNAs (ncRNAs). Recent studies have begun to explore the functional diversity and mechanistic role of these large ncRNAs. Here we synthesize these studies to provide an emerging model whereby large ncRNAs might achieve regulatory specificity through modularity, assembling diverse combinations of proteins and possibly RNA and DNA interactions.

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