Long Non-coding RNA in Gastrointestinal Cancer

Overview

Journal Front Oncol

Specialty Oncology

Date 2020 Feb 22

PMID 32083000

Citations 34

Authors

Agueda Martinez-Barriocanal

Diego Arango

Higinio Dopeso

Affiliations

Soon will be listed here.

Abstract

Whole genome and transcriptome sequencing technologies have led to the identification of many long non-coding RNAs (lncRNAs) and stimulated the research of their role in health and disease. LncRNAs participate in the regulation of critical signaling pathways including cell growth, motility, apoptosis, and differentiation; and their expression has been found dysregulated in human tumors. Thus, lncRNAs have emerged as new players in the initiation, maintenance and progression of tumorigenesis. (plasmacytoma variant translocation 1) lncRNA is located on chromosomal 8q24.21, a large locus frequently amplified in human cancers and predictive of increased cancer risk in genome-wide association studies (GWAS). Combined, colorectal and gastric adenocarcinomas are the most frequent tumor malignancies and also the leading cause of cancer-related deaths worldwide. expression is elevated in gastrointestinal tumors and correlates with poor patient prognosis. In this review, we discuss the mechanisms of action underlying oncogenic role in colorectal and gastric cancer such as upregulation, miRNA production, competitive endogenous RNA (ceRNA) function, protein stabilization, and epigenetic regulation. We also illustrate the potential role of as prognostic biomarker and its relationship with resistance to current chemotherapeutic treatments.

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