PVT1: a Rising Star Among Oncogenic Long Noncoding RNAs

Overview

Journal Biomed Res Int

Publisher Wiley

Specialties Biomedical Engineering
Biotechnology
General Medicine

Date 2015 Apr 18

PMID 25883951

Citations 118

Authors

Teresa Colombo

Lorenzo Farina

Giuseppe Macino

Paola Paci

Affiliations

Soon will be listed here.

Abstract

It is becoming increasingly clear that short and long noncoding RNAs critically participate in the regulation of cell growth, differentiation, and (mis)function. However, while the functional characterization of short non-coding RNAs has been reaching maturity, there is still a paucity of well characterized long noncoding RNAs, even though large studies in recent years are rapidly increasing the number of annotated ones. The long noncoding RNA PVT1 is encoded by a gene that has been long known since it resides in the well-known cancer risk region 8q24. However, a couple of accidental concurrent conditions have slowed down the study of this gene, that is, a preconception on the primacy of the protein-coding over noncoding RNAs and the prevalent interest in its neighbor MYC oncogene. Recent studies have brought PVT1 under the spotlight suggesting interesting models of functioning, such as competing endogenous RNA activity and regulation of protein stability of important oncogenes, primarily of the MYC oncogene. Despite some advancements in modelling the PVT1 role in cancer, there are many questions that remain unanswered concerning the precise molecular mechanisms underlying its functioning.

Citing Articles

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References

Caron H, Peter M, van Sluis P, Speleman F, de Kraker J, Laureys G . Evidence for two tumour suppressor loci on chromosomal bands 1p35-36 involved in neuroblastoma: one probably imprinted, another associated with N-myc amplification. Hum Mol Genet. 1995; 4(4):535-9. DOI: 10.1093/hmg/4.4.535. View

Uno M, Wirschubsky Z, Wiener F, Klein G . Relationship between tumorigenicity and the dosage of lymphoma- vs. normal-parent-derived chromosome 15 in somatic cell hybrids between lymphoma cells with rearranged pvt-1 gene and normal cells. Int J Cancer. 1989; 44(2):353-9. DOI: 10.1002/ijc.2910440228. View

Carninci P, Kasukawa T, Katayama S, Gough J, Frith M, Maeda N . The transcriptional landscape of the mammalian genome. Science. 2005; 309(5740):1559-63. DOI: 10.1126/science.1112014. View

Stratton M, Campbell P, Futreal P . The cancer genome. Nature. 2009; 458(7239):719-24. PMC: 2821689. DOI: 10.1038/nature07943. View

Paci P, Colombo T, Farina L . Computational analysis identifies a sponge interaction network between long non-coding RNAs and messenger RNAs in human breast cancer. BMC Syst Biol. 2014; 8:83. PMC: 4113672. DOI: 10.1186/1752-0509-8-83. View

Enciso-Mora V, Broderick P, Ma Y, Jarrett R, Hjalgrim H, Hemminki K . A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3). Nat Genet. 2010; 42(12):1126-1130. PMC: 4268499. DOI: 10.1038/ng.696. View

Huppi K, Siwarski D . Chimeric transcripts with an open reading frame are generated as a result of translocation to the Pvt-1 region in mouse B-cell tumors. Int J Cancer. 1994; 59(6):848-51. DOI: 10.1002/ijc.2910590623. View

Birney E, Stamatoyannopoulos J, Dutta A, Guigo R, Gingeras T, Margulies E . Identification and analysis of functional elements in 1% of the human genome by the ENCODE pilot project. Nature. 2007; 447(7146):799-816. PMC: 2212820. DOI: 10.1038/nature05874. View

Forrest A, Kawaji H, Rehli M, Baillie J, de Hoon M, Haberle V . A promoter-level mammalian expression atlas. Nature. 2014; 507(7493):462-70. PMC: 4529748. DOI: 10.1038/nature13182. View

10.

Huppi K, Volfovsky N, Runfola T, Jones T, Mackiewicz M, Martin S . The identification of microRNAs in a genomically unstable region of human chromosome 8q24. Mol Cancer Res. 2008; 6(2):212-21. DOI: 10.1158/1541-7786.MCR-07-0105. View

11.

Ala U, Karreth F, Bosia C, Pagnani A, Taulli R, Leopold V . Integrated transcriptional and competitive endogenous RNA networks are cross-regulated in permissive molecular environments. Proc Natl Acad Sci U S A. 2013; 110(18):7154-9. PMC: 3645534. DOI: 10.1073/pnas.1222509110. View

12.

Du M, Yuan T, Schilter K, Dittmar R, Mackinnon A, Huang X . Prostate cancer risk locus at 8q24 as a regulatory hub by physical interactions with multiple genomic loci across the genome. Hum Mol Genet. 2014; 24(1):154-66. PMC: 4262497. DOI: 10.1093/hmg/ddu426. View

13.

Brooksbank C, Bergman M, Apweiler R, Birney E, Thornton J . The European Bioinformatics Institute's data resources 2014. Nucleic Acids Res. 2013; 42(Database issue):D18-25. PMC: 3964968. DOI: 10.1093/nar/gkt1206. View

14.

Tay Y, Karreth F, Pandolfi P . Aberrant ceRNA activity drives lung cancer. Cell Res. 2014; 24(3):259-60. PMC: 3945890. DOI: 10.1038/cr.2014.21. View

15.

Huppi K, Pitt J, Wahlberg B, Caplen N . The 8q24 gene desert: an oasis of non-coding transcriptional activity. Front Genet. 2012; 3:69. PMC: 3339310. DOI: 10.3389/fgene.2012.00069. View

16.

Lercher M, Urrutia A, Hurst L . Clustering of housekeeping genes provides a unified model of gene order in the human genome. Nat Genet. 2002; 31(2):180-3. DOI: 10.1038/ng887. View

17.

Filipowicz W, Bhattacharyya S, Sonenberg N . Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?. Nat Rev Genet. 2008; 9(2):102-14. DOI: 10.1038/nrg2290. View

18.

Northcott P, Shih D, Peacock J, Garzia L, Morrissy A, Zichner T . Subgroup-specific structural variation across 1,000 medulloblastoma genomes. Nature. 2012; 488(7409):49-56. PMC: 3683624. DOI: 10.1038/nature11327. View

19.

Ferreira R, Pan-Hammarstrom Q, Graham R, Gateva V, Fontan G, Lee A . Association of IFIH1 and other autoimmunity risk alleles with selective IgA deficiency. Nat Genet. 2010; 42(9):777-80. DOI: 10.1038/ng.644. View

20.

Blyth K, Cameron E, Neil J . The RUNX genes: gain or loss of function in cancer. Nat Rev Cancer. 2005; 5(5):376-87. DOI: 10.1038/nrc1607. View