» Articles » PMID: 26457013

Capsule Endoscopy of the Future: What's on the Horizon?

Overview
Specialty Gastroenterology
Date 2015 Oct 13
PMID 26457013
Citations 15
Authors
Affiliations
Soon will be listed here.
Abstract

Capsule endoscopes have evolved from passively moving diagnostic devices to actively moving systems with potential therapeutic capability. In this review, we will discuss the state of the art, define the current shortcomings of capsule endoscopy, and address research areas that aim to overcome said shortcomings. Developments in capsule mobility schemes are emphasized in this text, with magnetic actuation being the most promising endeavor. Research groups are working to integrate sensor data and fuse it with robotic control to outperform today's standard invasive procedures, but in a less intrusive manner. With recent advances in areas such as mobility, drug delivery, and therapeutics, we foresee a translation of interventional capsule technology from the bench-top to the clinical setting within the next 10 years.

Citing Articles

Advances in gastrointestinal vascular bleeding disorders: Successful sirolimus treatment in colonic angioectasia.

Sun Q, Wang X, Li D, Li B, Tu X, Jiang Z World J Gastroenterol. 2025; 31(4):100718.

PMID: 39877708 PMC: 11718635. DOI: 10.3748/wjg.v31.i4.100718.


Design and Evaluation of ScanCap: A Low-Cost, Reusable Tethered Capsule Endoscope with Blue-Green Illumination Imaging for Unsedated Screening and Early Detection of Barrett's Esophagus.

Hicheri C, Azimuddin A, Kortum A, Bailey J, Tang Y, Schwarz R Bioengineering (Basel). 2024; 11(6.

PMID: 38927792 PMC: 11200367. DOI: 10.3390/bioengineering11060557.


Robotic, self-propelled, self-steerable, and disposable colonoscopes: Reality or pipe dream? A state of the art review.

Winters C, Subramanian V, Valdastri P World J Gastroenterol. 2022; 28(35):5093-5110.

PMID: 36188716 PMC: 9516669. DOI: 10.3748/wjg.v28.i35.5093.


Endoscopic capsule robot-based diagnosis, navigation and localization in the gastrointestinal tract.

Hanscom M, Cave D Front Robot AI. 2022; 9:896028.

PMID: 36119725 PMC: 9479458. DOI: 10.3389/frobt.2022.896028.


Efficacy and safety of vibrating capsule for functional constipation (VICONS): A randomised, double-blind, placebo-controlled, multicenter trial.

Zhu J, Qian Y, Pan J, He C, Lan Y, Chen W EClinicalMedicine. 2022; 47:101407.

PMID: 35518121 PMC: 9062239. DOI: 10.1016/j.eclinm.2022.101407.


References
1.
Terry B, Lyle A, Schoen J, Rentschler M . Preliminary mechanical characterization of the small bowel for in vivo robotic mobility. J Biomech Eng. 2011; 133(9):091010. PMC: 5413140. DOI: 10.1115/1.4005168. View

2.
Menciassi A, Stefanini C, Gorini S, Pernorio G, Kim B, Park J . Locomotion of a legged capsule in the gastrointestinal tract: theoretical study and preliminary technological results. Conf Proc IEEE Eng Med Biol Soc. 2007; 2004:2767-70. DOI: 10.1109/IEMBS.2004.1403791. View

3.
Miftahof R . The wave phenomena in smooth muscle syncytia. In Silico Biol. 2006; 5(5-6):479-98. View

4.
CROSBY W, KUGLER H . Intraluminal biopsy of the small intestine; the intestinal biopsy capsule. Am J Dig Dis. 1957; 2(5):236-41. DOI: 10.1007/BF02231100. View

5.
Valdastri P, Quaglia C, Susilo E, Menciassi A, Dario P, Ho C . Wireless therapeutic endoscopic capsule: in vivo experiment. Endoscopy. 2008; 40(12):979-82. DOI: 10.1055/s-0028-1103424. View