Role of Pentraxin 3 in Shaping Arthritogenic Alphaviral Disease: from Enhanced Viral Replication to Immunomodulation

Overview

Journal PLoS Pathog

Specialty Microbiology

Date 2015 Feb 20

PMID 25695775

Citations 24

Authors

Suan-Sin Foo

Weiqiang Chen

Adam Taylor

Kuo-Ching Sheng

Xing Yu

Terk-Shin Teng

Patrick C Reading

Helen Blanchard

Cecilia Garlanda

Alberto Mantovani

Lisa F P Ng

Lara J Herrero

Suresh Mahalingam

Affiliations

Soon will be listed here.

Abstract

The rising prevalence of arthritogenic alphavirus infections, including chikungunya virus (CHIKV) and Ross River virus (RRV), and the lack of antiviral treatments highlight the potential threat of a global alphavirus pandemic. The immune responses underlying alphavirus virulence remain enigmatic. We found that pentraxin 3 (PTX3) was highly expressed in CHIKV and RRV patients during acute disease. Overt expression of PTX3 in CHIKV patients was associated with increased viral load and disease severity. PTX3-deficient (PTX3(-/-)) mice acutely infected with RRV exhibited delayed disease progression and rapid recovery through diminished inflammatory responses and viral replication. Furthermore, binding of the N-terminal domain of PTX3 to RRV facilitated viral entry and replication. Thus, our study demonstrates the pivotal role of PTX3 in shaping alphavirus-triggered immunity and disease and provides new insights into alphavirus pathogenesis.

Citing Articles

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