The Long Pentraxin PTX3 As a Humoral Innate Immunity Functional Player and Biomarker of Infections and Sepsis

Overview

Journal Front Immunol

Specialty Allergy & Immunology

Date 2019 Apr 30

PMID 31031772

Citations 63

Authors

Remi Porte

Sadaf Davoudian

Fatemeh Asgari

Raffaella Parente

Alberto Mantovani

Cecilia Garlanda

Barbara Bottazzi

Affiliations

Soon will be listed here.

Abstract

The first line of defense in innate immunity is provided by cellular and humoral mediators. Pentraxins are a superfamily of phylogenetically conserved humoral mediators of innate immunity. PTX3, the first long pentraxin identified, is a soluble pattern recognition molecule rapidly produced by several cell types in response to primary pro-inflammatory signals and microbial recognition. PTX3 acts as an important mediator of innate immunity against pathogens of fungal, bacterial and viral origin, and as a regulator of inflammation, by modulating complement activation and cell extravasation, and facilitating pathogen recognition by myeloid cells. In sepsis, PTX3 plasma levels are associated with severity of the condition, patient survival, and response to therapy. In combination with other established biomarkers, PTX3 could improve stratification of sepsis patients and thus, complement the system of classification and monitoring of this disease.

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References

Dias A, Goodman A, Dos Santos J, Gomes R, Altmeyer A, Bozza P . TSG-14 transgenic mice have improved survival to endotoxemia and to CLP-induced sepsis. J Leukoc Biol. 2001; 69(6):928-36. View

Muller B, Peri G, Doni A, Torri V, Landmann R, Bottazzi B . Circulating levels of the long pentraxin PTX3 correlate with severity of infection in critically ill patients. Crit Care Med. 2001; 29(7):1404-7. DOI: 10.1097/00003246-200107000-00017. View

Garlanda C, Hirsch E, Bozza S, Salustri A, De Acetis M, Nota R . Non-redundant role of the long pentraxin PTX3 in anti-fungal innate immune response. Nature. 2002; 420(6912):182-6. DOI: 10.1038/nature01195. View

Nauta A, Bottazzi B, Mantovani A, Salvatori G, Kishore U, Schwaeble W . Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur J Immunol. 2003; 33(2):465-73. DOI: 10.1002/immu.200310022. View

Diniz S, Nomizo R, Cisalpino P, Teixeira M, Brown G, Mantovani A . PTX3 function as an opsonin for the dectin-1-dependent internalization of zymosan by macrophages. J Leukoc Biol. 2004; 75(4):649-56. DOI: 10.1189/jlb.0803371. View

Gibot S, Cravoisy A, Levy B, Bene M, Faure G, Bollaert P . Soluble triggering receptor expressed on myeloid cells and the diagnosis of pneumonia. N Engl J Med. 2004; 350(5):451-8. DOI: 10.1056/NEJMoa031544. View

Latini R, Maggioni A, Peri G, Gonzini L, Lucci D, Mocarelli P . Prognostic significance of the long pentraxin PTX3 in acute myocardial infarction. Circulation. 2004; 110(16):2349-54. DOI: 10.1161/01.CIR.0000145167.30987.2E. View

Gaziano R, Bozza S, Bellocchio S, Perruccio K, Montagnoli C, Pitzurra L . Anti-Aspergillus fumigatus efficacy of pentraxin 3 alone and in combination with antifungals. Antimicrob Agents Chemother. 2004; 48(11):4414-21. PMC: 525434. DOI: 10.1128/AAC.48.11.4414-4421.2004. View

Azzurri A, Sow O, Amedei A, Bah B, Diallo S, Peri G . IFN-gamma-inducible protein 10 and pentraxin 3 plasma levels are tools for monitoring inflammation and disease activity in Mycobacterium tuberculosis infection. Microbes Infect. 2005; 7(1):1-8. DOI: 10.1016/j.micinf.2004.09.004. View

10.

Garlanda C, Bottazzi B, Bastone A, Mantovani A . Pentraxins at the crossroads between innate immunity, inflammation, matrix deposition, and female fertility. Annu Rev Immunol. 2005; 23:337-66. DOI: 10.1146/annurev.immunol.23.021704.115756. View

11.

Jarva H, Ram S, Vogel U, Blom A, Meri S . Binding of the complement inhibitor C4bp to serogroup B Neisseria meningitidis. J Immunol. 2005; 174(10):6299-307. DOI: 10.4049/jimmunol.174.10.6299. View

12.

Mairuhu A, Peri G, Setiati T, Hack C, Koraka P, Soemantri A . Elevated plasma levels of the long pentraxin, pentraxin 3, in severe dengue virus infections. J Med Virol. 2005; 76(4):547-52. DOI: 10.1002/jmv.20397. View

13.

Baruah P, Dumitriu I, Peri G, Russo V, Mantovani A, Manfredi A . The tissue pentraxin PTX3 limits C1q-mediated complement activation and phagocytosis of apoptotic cells by dendritic cells. J Leukoc Biol. 2006; 80(1):87-95. DOI: 10.1189/jlb.0805445. View

14.

Soares A, Souza D, Pinho V, Vieira A, Nicoli J, Cunha F . Dual function of the long pentraxin PTX3 in resistance against pulmonary infection with Klebsiella pneumoniae in transgenic mice. Microbes Infect. 2006; 8(5):1321-9. DOI: 10.1016/j.micinf.2005.12.017. View

15.

Uzzan B, Cohen R, Nicolas P, Cucherat M, Perret G . Procalcitonin as a diagnostic test for sepsis in critically ill adults and after surgery or trauma: a systematic review and meta-analysis. Crit Care Med. 2006; 34(7):1996-2003. DOI: 10.1097/01.CCM.0000226413.54364.36. View

16.

Bozza S, Bistoni F, Gaziano R, Pitzurra L, Zelante T, Bonifazi P . Pentraxin 3 protects from MCMV infection and reactivation through TLR sensing pathways leading to IRF3 activation. Blood. 2006; 108(10):3387-96. DOI: 10.1182/blood-2006-03-009266. View

17.

Inoue K, Sugiyama A, Reid P, Ito Y, Miyauchi K, Mukai S . Establishment of a high sensitivity plasma assay for human pentraxin3 as a marker for unstable angina pectoris. Arterioscler Thromb Vasc Biol. 2006; 27(1):161-7. DOI: 10.1161/01.ATV.0000252126.48375.d5. View

18.

Jaillon S, Peri G, Delneste Y, Fremaux I, Doni A, Moalli F . The humoral pattern recognition receptor PTX3 is stored in neutrophil granules and localizes in extracellular traps. J Exp Med. 2007; 204(4):793-804. PMC: 2118544. DOI: 10.1084/jem.20061301. View

19.

Olesen R, Wejse C, Velez D, Bisseye C, Sodemann M, Aaby P . DC-SIGN (CD209), pentraxin 3 and vitamin D receptor gene variants associate with pulmonary tuberculosis risk in West Africans. Genes Immun. 2007; 8(6):456-67. DOI: 10.1038/sj.gene.6364410. View

20.

Tong M, Carrero J, Qureshi A, Anderstam B, Heimburger O, Barany P . Plasma pentraxin 3 in patients with chronic kidney disease: associations with renal function, protein-energy wasting, cardiovascular disease, and mortality. Clin J Am Soc Nephrol. 2007; 2(5):889-97. DOI: 10.2215/CJN.00870207. View