Patrick C Reading
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Explore the profile of Patrick C Reading including associated specialties, affiliations and a list of published articles.
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128
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4784
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Recent Articles
1.
Premachandre C, Quah P, Tran B, Vincan E, Deliyannis G, Wong C, et al.
Vet Microbiol
. 2024 Dec;
300:110340.
PMID: 39675119
In vitro three-dimensional organoid models simulate key aspects of the structure and function of in vivo organs and have been used to study physiology, host-pathogen interactions, pathogenesis and pharmacodynamics. Although...
2.
Tessema M, Feng S, Enosi Tuipulotu D, Farrukee R, Ngo C, Gago da Graca C, et al.
Commun Biol
. 2024 Aug;
7(1):1050.
PMID: 39183326
Dynamin-like GTPase proteins, including myxoma (Mx) and guanylate-binding proteins (GBPs), are among the many interferon stimulated genes induced following viral infections. While studies report that human (h)GBPs inhibit different viruses...
3.
Jia X, Crawford J, Gebregzabher D, Monson E, Mettelman R, Wan Y, et al.
Cell
. 2024 Aug;
187(17):4586-4604.e20.
PMID: 39137778
Respiratory infections cause significant morbidity and mortality, yet it is unclear why some individuals succumb to severe disease. In patients hospitalized with avian A(H7N9) influenza, we investigated early drivers underpinning...
4.
Farrukee R, Schwab L, Barnes J, Brooks A, Londrigan S, Hartmann G, et al.
Sci Rep
. 2024 Jun;
14(1):13524.
PMID: 38866913
Myxovirus resistance (Mx) proteins are products of interferon stimulated genes (ISGs) and Mx proteins of different species have been reported to mediate antiviral activity against a number of viruses, including...
5.
Verzele N, Chua B, Short K, Moe A, Edwards I, Bielefeldt-Ohmann H, et al.
PLoS Pathog
. 2024 Apr;
20(4):e1011635.
PMID: 38626267
Influenza A virus (IAV) is a common respiratory pathogen and a global cause of significant and often severe morbidity. Although inflammatory immune responses to IAV infections are well described, little...
6.
Jalali S, Stankovic S, Westall G, Reading P, Sullivan L, Brooks A
Transpl Immunol
. 2023 Nov;
82:101962.
PMID: 38007172
Background: Human natural killer (NK) cells and gamma delta (γδ) T cells may impact outcomes of solid organ transplantation (SOT) such as lung transplantation (LTx) following the differential engagement of...
7.
Chappell K, Mordant F, Amarilla A, Modhiran N, Liang B, Li Z, et al.
EBioMedicine
. 2023 Oct;
97:104842.
PMID: 37865043
Background: We previously demonstrated the safety and immunogenicity of an MF59-adjuvanted COVID-19 vaccine based on the SARS-CoV-2 spike glycoprotein stabilised in a pre-fusion conformation by a molecular clamp using HIV-1...
8.
Zheng M, Tan T, Villalon-Letelier F, Lau H, Deng Y, Fritzlar S, et al.
Sci Adv
. 2023 Sep;
9(36):eadg3469.
PMID: 37683004
Influenza virus-specific tissue-resident memory (Trm) CD8 T cells located along the respiratory tract provide cross-strain protection against a breadth of influenza viruses. We show that immunization with a single-cycle influenza...
9.
Nigos L, Scott N, Brooks A, Ait-Goughoulte M, Londrigan S, Reading P, et al.
Pathogens
. 2023 Jun;
12(6).
PMID: 37375542
Host cell restriction factors are intracellular proteins that can inhibit virus replication. Characterisation of novel host cell restriction factors can provide potential targets for host-directed therapies. In this study, we...
10.
Mifsud E, Farrukee R, Hurt A, Reading P, Barr I
FEMS Microbes
. 2023 Jun;
3:xtac011.
PMID: 37332495
It is well-established that influenza virus infections predispose individuals to secondary bacterial infections (SBIs), which may result in a range of clinical outcomes from relatively mild (e.g. sinusitis and otitis...