The Dual Complexity of PTX3 in Health and Disease: A Balancing Act?

Overview

Journal Trends Mol Med

Specialties General Medicine
Molecular Biology

Date 2016 May 16

PMID 27179743

Citations 43

Authors

Elena Magrini

Alberto Mantovani

Cecilia Garlanda

Affiliations

Soon will be listed here.

Abstract

The humoral arm of innate immunity is complex and includes various molecules that serve as markers of inflammation with complementary characteristics, such as the short pentraxins C-reactive protein (CRP) and serum amyloid P (SAP) and the long pentraxin PTX3. There is a growing amount of evidence - including mouse and human genetics - that suggests that PTX3 is essential in conferring host resistance against selected pathogens and, moreover, that it plays a dual antagonistic role in the regulation of inflammation. Dissection of such a yin-and-yang role of pentraxins in immunity and inflammation is timely and significant as it may pave the way for better clinical exploitation against various diseases.

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