Enantioselective Annulations for Dihydroquinolones by in Situ Generation of Azolium Enolates

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2014 Jul 15

PMID 25017004

Citations 17

Authors

Anna Lee

Ashkaan Younai

Christopher K Price

Javier Izquierdo

Rama K Mishra

Karl A Scheidt

Affiliations

Soon will be listed here.

Abstract

A convergent, catalytic asymmetric formal [4 + 2] annulation for the synthesis of dihydroquinolones has been developed. Carboxylic acids can be employed as precursors to NHC enolates through an in situ activation strategy. Simultaneous generation of a reactive aza-o-quinone methide under the basic conditions employed for NHC generation leads to a dual activation approach.

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