Karl A Scheidt
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Explore the profile of Karl A Scheidt including associated specialties, affiliations and a list of published articles.
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171
Citations
3042
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Recent Articles
1.
Campos M, Riha I, Zhang C, Mozes C, Scheidt K, Zhang X
ACS Chem Biol
. 2025 Jan;
20(2):479-488.
PMID: 39882752
Conventional small-molecule drugs primarily operate by inhibiting protein function, but this approach is limited when proteins lack well-defined ligand-binding pockets. Targeted protein degradation (TPD) offers an alternative approach by harnessing...
2.
Qiao F, Binkowski T, Broughan I, Chen W, Natarajan A, Schiltz G, et al.
Cancers (Basel)
. 2024 Sep;
16(18).
PMID: 39335149
Drug discovery historically starts with an established function, either that of compounds or proteins. This can hamper discovery of novel therapeutics. As structure determines function, we hypothesized that unique 3D...
3.
Peng Q, Hwang M, Renteria-Gomez A, Mukherjee P, Young R, Qiu Y, et al.
Science
. 2024 Sep;
385(6716):1471-1477.
PMID: 39325876
The excitation of carbonyl compounds by light to generate radical intermediates has historically been restricted to ketones and aldehydes; carboxylic acids have been overlooked because of high energy requirements and...
4.
Rourke M, McGill M, Yang D, Farnam E, Zhu J, Scheidt K
Synlett
. 2024 Jul;
34(18):2175-2180.
PMID: 38948905
Potassium trifluoroborates have gained significant utility as coupling partners in organic synthesis, particularly in the Suzuki-Miyaura coupling reaction. Recently, they have also been used as radical precursors under oxidative conditions...
5.
Qiao F, Binknowski T, Broughan I, Chen W, Natarajan A, Schiltz G, et al.
bioRxiv
. 2024 Jun;
PMID: 38826221
Drug discovery starts with known function, either of a compound or a protein, in-turn prompting investigations to probe 3D structure of the compound-protein interface. As protein structure determines function, we...
6.
Wang P, Bay A, Farnam E, Scheidt K
Adv Synth Catal
. 2024 Mar;
365(14):2361-2366.
PMID: 38464363
A mild photocatalyzed approach to achieve the α-alkylation of esters via formation of an α -radical is disclosed here. Cesium enolates of esters were generated using CsCO as a base....
7.
Kim D, Orr M, Yu X, Munshi H, Wang A, Trudeau C, et al.
ACS Med Chem Lett
. 2024 Feb;
15(2):258-264.
PMID: 38352843
Glioblastoma, a prevalent malignant CNS tumor, presents a therapeutic challenge because of resistance to standard treatments, including radiation therapy and temozolomide. Both modalities induce autophagy, thereby paradoxically promoting tumor survival....
8.
Nam Y, Tam A, Miller E, Scheidt K
J Am Chem Soc
. 2023 Dec;
146(1):118-124.
PMID: 38153983
Corynantheine-type alkaloids are major components of the , also known as kratom, that exhibit unique pharmacological activity. However, no universal method to prepare these alkaloids has been reported. Disclosed herein...
9.
Cao J, Zhu J, Scheidt K
Chem Sci
. 2023 Dec;
15(1):154-159.
PMID: 38131082
Ketones are ubiquitous motifs in the realm of pharmaceuticals and natural products. Traditional approaches to accessing these species involve the addition of metal reagents to carboxyl compounds under harsh conditions....
10.
Rourke M, Wang C, Schull C, Scheidt K
ACS Catal
. 2023 Nov;
13(12):7987-7994.
PMID: 37969469
-Heteroatom functionalization is a key strategy for C-C bond formation in organic synthesis, as exemplified by the addition of a nucleophile to electrophilic functional groups, such as iminium ions; oxocarbenium...