Azaindole Synthesis Through Dual Activation Catalysis with N-heterocyclic Carbenes

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2016 Jul 2

PMID 27363788

Citations 1

Authors

Hayden A Sharma

M Todd Hovey

Karl A Scheidt

Affiliations

Soon will be listed here.

Abstract

A convergent, transition-metal-free synthesis of 2-aryl-azaindoles has been developed. The interception of a reactive aza-ortho-azaquinone methide intermediate by an acyl anion equivalent generated through carbene catalysis provides high yields, a wide substrate scope, and the synthesis of previously inaccessible azaindoles.

Citing Articles

Synthesis of Functionalized Tetrahydroquinoline Containing Indole Scaffold via Chemoselective Annulation of Aza--quinone Methide Precursor.

Zhang X, Xing Q, Gou Z, Gan S, Wang W, Li Z ACS Omega. 2023; 8(25):22352-22360.

PMID: 37396238 PMC: 10308564. DOI: 10.1021/acsomega.2c07036.

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