Enantioselective Activation of Stable Carboxylate Esters As Enolate Equivalents Via N-heterocyclic Carbene Catalysts

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2012 Apr 11

PMID 22486921

Citations 29

Authors

Lin Hao

Yu Du

Hui Lv

Xingkuan Chen

Huishen Jiang

Yaling Shao

Yonggui Robin Chi

Affiliations

Soon will be listed here.

Abstract

The first N-Heterocyclic Carbene (NHC) mediated activation of stable carboxylate esters to generate enolate intermediates is disclosed. The catalytically generated arylacetic ester enolates undergo enantioselective reactions with α,β-unsaturated imines.

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