Controlled β-protonation and [4+2] Cycloaddition of Enals and Chalcones Via N-heterocyclic Carbene/acid Catalysis: Toward Substrate Independent Reaction Control

Overview

Journal Chem Commun (Camb)

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2012 Nov 23

PMID 23171999

Citations 12

Authors

Zhenqian Fu

Hui Sun

Shaojin Chen

Bhoopendra Tiwari

Guohui Li

Yonggui Robin Chi

Affiliations

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Abstract

A substrate-independent selective generation of enolates over homoenolate equivalents in NHC-catalyzed reactions of enals and chalcones is disclosed. Acid co-catalysts play vital roles in control of the reaction pathways, allowing for individual access to diverse products from identical substrates.

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