Enantioselective N-heterocyclic Carbene Catalyzed Annulation Reactions with Imidazolidinones

Overview

Journal Angew Chem Int Ed Engl

Specialty Chemistry

Date 2013 Nov 20

PMID 24249661

Citations 10

Authors

Elizabeth OBryan McCusker

Karl A Scheidt

Affiliations

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Abstract

Add acetic acid: A highly stereoselective N-heterocyclic carbene (NHC)-catalyzed formal [4+2] annulation between α,β-unsaturated aldehydes and imidazolidinones for the synthesis of imidazoles has been developed. Acetic acid serves as a key additive to achieve high chemoselectivity for the formal [4+2] annulation product.

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