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Tomographic Lifetime Imaging Using Combined Early- and Late-arriving Photons

Overview
Journal Opt Lett
Specialty Ophthalmology
Date 2014 Apr 3
PMID 24690697
Citations 11
Authors
Steven S Hou
William L Rice
Brian J Bacskai
Anand T N Kumar
Affiliations
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Abstract

We present a novel, hybrid approach for time domain fluorescence tomography that efficiently combines lifetime multiplexing using late-arriving or asymptotic photons, with the high spatial resolution capability of early photon tomography. We also show that a decay amplitude-based asymptotic approach is superior to direct inversion of late-arriving photons for tomographic lifetime imaging within turbid media. The hybrid reconstruction approach is experimentally shown to recover fluorescent inclusions separated as close as 1.4 mm, with improved resolution and reduced cross talk compared to just using early photons or the asymptotic approach alone.

Citing Articles

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Comparison of tomographic fluorescence spectral and lifetime multiplexing.

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All Photons Imaging Through Volumetric Scattering.

Satat G, Heshmat B, Raviv D, Raskar R Sci Rep. 2016; 6:33946.

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