Brian J Bacskai
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Explore the profile of Brian J Bacskai including associated specialties, affiliations and a list of published articles.
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159
Citations
9358
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Recent Articles
1.
Hou S, Yang J, Kwon Y, Pian Q, Tang Y, Dauphinais C, et al.
bioRxiv
. 2025 Feb;
PMID: 39896645
Multiphoton microscopy serves as an essential tool for high-resolution imaging of the living mouse brain. To facilitate optical access to the brain during imaging, the cranial window surgery is commonly...
2.
Zhao Q, Yokomizo S, Perle S, Lee Y, Zhou H, Miller M, et al.
Sci Rep
. 2024 Oct;
14(1):23044.
PMID: 39362954
Alzheimer's disease (AD) is a progressive neurodegenerative condition marked by memory impairments and distinct histopathological features such as amyloid-beta (Aβ) accumulations. Alzheimer's patients experience sleep disturbances at early stages of...
3.
Hou S, Ikegawa Y, Kwon Y, Wieckiewicz N, Houser M, Lundin B, et al.
Elife
. 2024 Oct;
13.
PMID: 39360803
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Förster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity...
4.
Kozberg M, Munting L, Maresco L, Auger C, van den Berg M, Denis de Senneville B, et al.
bioRxiv
. 2024 May;
PMID: 38746419
Background: Cerebral amyloid angiopathy (CAA) is a cerebral small vessel disease in which amyloid-β accumulates in vessel walls. CAA is a leading cause of symptomatic lobar intracerebral hemorrhage and an...
5.
Miller M, Lariviere L, Pagnier G, Aygar S, Wieckiewicz N, Maesako M, et al.
J Alzheimers Dis
. 2024 Apr;
99(2):477-483.
PMID: 38669543
Alzheimer's disease (AD) is a progressive neurodegenerative disease with limited therapeutic strategies. NB-02 is a novel botanical drug that has shown promise as a protective and therapeutic treatment for AD...
6.
Gillani R, Kironde E, Whiteman S, Zwang T, Bacskai B
Brain Behav Immun
. 2024 Mar;
119:251-260.
PMID: 38552924
Synapses are lost on a massive scale in the brain and spinal cord of people living with multiple sclerosis (PwMS), and this synaptic loss extends far beyond demyelinating lesions. Post-mortem...
7.
Hou S, Ikegawa Y, Kwon Y, Wieckiewicz N, Houser M, Lundin B, et al.
bioRxiv
. 2024 Feb;
PMID: 38352497
γ-Secretase plays a pivotal role in the central nervous system. Our recent development of genetically encoded Forster resonance energy transfer (FRET)-based biosensors has enabled the spatiotemporal recording of γ-secretase activity...
8.
Gillani R, Kironde E, Whiteman S, Zwang T, Bacskai B
bioRxiv
. 2024 Feb;
PMID: 38328177
Synapses are lost on a massive scale in the brain and spinal cord of people living with multiple sclerosis (PwMS), and this synaptic loss extends far beyond demyelinating lesions. Post-mortem...
9.
Calvo-Rodriguez M, Kharitonova E, Snyder A, Hou S, Sanchez-Mico M, Das S, et al.
Mol Neurodegener
. 2024 Jan;
19(1):6.
PMID: 38238819
Background: Reactive oxidative stress is a critical player in the amyloid beta (Aβ) toxicity that contributes to neurodegeneration in Alzheimer's disease (AD). Damaged mitochondria are one of the main sources...
10.
Zhao Q, Maci M, Miller M, Zhou H, Zhang F, Algamal M, et al.
Mol Neurodegener
. 2023 Dec;
18(1):93.
PMID: 38041158
Background: Alzheimer's disease (AD) patients exhibit memory disruptions and profound sleep disturbances, including disruption of deep non-rapid eye movement (NREM) sleep. Slow-wave activity (SWA) is a major restorative feature of...