Transition-metal-free Amination Phosphoryl Azide for the Synthesis of Phosphoramidates

Overview

Journal RSC Adv

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2022 May 6

PMID 35521381

Authors

Qing Li

Xiaohua Sun

Xiaoqin Yang

Minghu Wu

Shaofa Sun

Xiuling Chen

Affiliations

Soon will be listed here.

Abstract

A facile and efficient approach to phosphoramidates was developed amination of phosphoryl azides. A variety of phosphoramidates were obtained in one step with good to excellent yields under a mild reaction system. The process uses easily available amines as a N source and offers a new opportunity for P-N bond formation.

Citing Articles

Base-promoted direct amidation of esters: beyond the current scope and practical applications.

Slavchev I, Ward J, Rissanen K, Dobrikov G, Simeonov S RSC Adv. 2022; 12(32):20555-20562.

PMID: 35919171 PMC: 9284525. DOI: 10.1039/d2ra03524c.

Opening up the Toolbox: Synthesis and Mechanisms of Phosphoramidates.

Itumoh E, Data S, Leitao E Molecules. 2020; 25(16).

PMID: 32823507 PMC: 7463754. DOI: 10.3390/molecules25163684.

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