Cobalt Catalyzed Sp C-H Amination Utilizing Aryl Azides

Overview

Journal Chem Sci

Publisher Royal Society of Chemistry

Specialty Chemistry

Date 2018 Feb 14

PMID 29435216

Citations 12

Authors

Omar Villanueva

Nina Mace Weldy

Simon B Blakey

Cora E Macbeth

Affiliations

Soon will be listed here.

Abstract

A dinuclear Co(ii) complex supported by a modular, tunable redox-active ligand system is capable of selective C-H amination to form indolines from aryl azides in good yields at low (1 mol%) catalyst loading. The reaction is tolerant of medicinally relevant heterocycles, such as pyridine and indole, and can be used to form 5-, 6-, and 7-membered rings. The synthetic versatility obtained using low loadings of an earth abundant transition metal complex represents a significant advance in catalytic C-H amination technology.

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