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Variants in FAM13A Are Associated with Chronic Obstructive Pulmonary Disease

Overview
Journal Nat Genet
Specialty Genetics
Date 2010 Feb 23
PMID 20173748
Citations 225
Authors
Michael H Cho
Nadia Boutaoui
Barbara J Klanderman
Jody S Sylvia
John P Ziniti
Craig P Hersh
Dawn L DeMeo
Gary M Hunninghake
Augusto A Litonjua
David Sparrow
Christoph Lange
Sungho Won
James R Murphy
Terri H Beaty
Elizabeth A Regan
Barry J Make
John E Hokanson
James D Crapo
Xiangyang Kong
Wayne H Anderson
Ruth Tal-Singer
David A Lomas
Per Bakke
Amund Gulsvik
Sreekumar G Pillai
Edwin K Silverman
Affiliations
Soon will be listed here.
Abstract

We performed a genome-wide association study for chronic obstructive pulmonary disease (COPD) in three population cohorts, including 2,940 cases and 1,380 controls who were current or former smokers with normal lung function. We identified a new susceptibility locus at 4q22.1 in FAM13A and replicated this association in one case-control group (n = 1,006) and two family-based cohorts (n = 3,808) (rs7671167, combined P = 1.2 x 10(-11), combined odds ratio in case-control studies 0.76, 95% confidence interval 0.69-0.83).

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