Craig P Hersh
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Explore the profile of Craig P Hersh including associated specialties, affiliations and a list of published articles.
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224
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5889
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Recent Articles
1.
Ghosh A, Coyne L, Panda S, Menon A, Moll M, Archer M, et al.
BMC Genomics
. 2025 Mar;
26(1):227.
PMID: 40065206
Background: Few cohorts have study populations large enough to conduct molecular analysis of ex vivo lung tissue for genomic analyses. Transcriptome imputation is a non-invasive alternative with many potential applications....
2.
Orchard P, Blackwell T, Kachuri L, Castaldi P, Cho M, Christenson S, et al.
medRxiv
. 2025 Mar;
PMID: 40034763
Most genetic variants associated with complex traits and diseases occur in non-coding genomic regions and are hypothesized to regulate gene expression. To understand the genetics underlying gene expression variability, we...
3.
Saferali A, Wienecke A, Xu Z, Liu T, Sheynkman G, Hersh C, et al.
Eur Respir J
. 2025 Feb;
PMID: 39978861
Background: Identification of COPD disease-causing genes is an important tool for understanding why COPD develops, who is at highest COPD risk, and how new COPD treatments can be developed. Previous...
4.
Tiwari A, Hobbs B, Sharma R, Li J, Kho A, Amr S, et al.
Respir Res
. 2025 Jan;
26(1):38.
PMID: 39856653
Background: MicroRNAs (miRNAs) are crucial post-transcriptional regulators involved in inflammatory diseases, such as asthma. Poor lung function and airflow issues in childhood are linked to the development of chronic obstructive...
5.
Ryu M, Yun J, Kim K, Gentili M, Ghosh A, Sciurba F, et al.
BMC Genomics
. 2024 Dec;
25(1):1192.
PMID: 39695952
Background: Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are debilitating diseases associated with divergent histopathological changes in the lungs. At present, due to cost and technical limitations,...
6.
Nguyen H, Jeong Y, Kim Y, Kamiya M, Kim Y, Athar H, et al.
Proc Natl Acad Sci U S A
. 2024 Dec;
121(50):e2401899121.
PMID: 39636853
Fibrosis drives end-organ damage in many diseases. However, clinical trials targeting individual upstream activators of fibroblasts, such as TGFβ, have largely failed. Here, we target the leukemia inhibitory factor receptor...
7.
Fangal V, Saferali A, Castaldi P, Hersh C, Weiss S
EBioMedicine
. 2024 Nov;
110:105453.
PMID: 39580967
Background: The clinical and pathological features of asthma and chronic obstructive pulmonary disease (COPD) can converge in smokers and elderly individuals as asthma-COPD overlap (ACO). This overlap challenges the diagnosis...
8.
Moll M, Hecker J, Platig J, Zhang J, Ghosh A, Pratte K, et al.
EBioMedicine
. 2024 Nov;
110:105429.
PMID: 39509750
Background: Genetic variants and gene expression predict risk of chronic obstructive pulmonary disease (COPD), but their effect on COPD heterogeneity is unclear. We aimed to define high-risk COPD subtypes using...
9.
Gentili M, Glass K, Maiorino E, Hobbs B, Xu Z, Castaldi P, et al.
PLoS Comput Biol
. 2024 Oct;
20(10):e1011079.
PMID: 39418301
Chronic obstructive pulmonary disease (COPD) is a complex disease influenced by well-established environmental exposures (most notably, cigarette smoking) and incompletely defined genetic factors. The chromosome 4q region harbors multiple genetic...
10.
Moll M, Xu Z, Boueiz A, Ryu M, Silverman E, Cho M, et al.
medRxiv
. 2024 Oct;
PMID: 39417147
Rationale: Cigarette smoking (CS) impairs B cell function and antibody production, increasing infection risk. The impact of e-cigarette use ('vaping') and combined CS and vaping ('dual-use') on B cell activity...