Synthesis and Evaluation of 3''- and 4''-deoxy and -fluoro Analogs of the Immunostimulatory Glycolipid, KRN7000

Overview

Journal Bioorg Med Chem Lett

Specialty Biochemistry

Date 2009 Jun 19

PMID 19535248

Citations 20

Authors

Ravinder Raju

Bernard F Castillo

Stewart K Richardson

Meena Thakur

Ryan Severins

Mitchell Kronenberg

Amy R Howell

Affiliations

Soon will be listed here.

Abstract

Four 3''- and 4''-deoxy and -fluorogalactosyl ceramides were synthesized, and their ability to stimulate iNKT cells, based on levels of IL-2 production, was assessed in three NKT cell receptor hybridomas. In two of the hybridomas, 1.2 and 2H4, all of the analogs were immunostimulatory, while in the 1.4 hybridoma only the 4''-fluoro analog led to the production of significant levels of IL-2.

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