Structure-based Discovery of Glycolipids for CD1d-mediated NKT Cell Activation: Tuning the Adjuvant Versus Immunosuppression Activity

Overview

Journal J Am Chem Soc

Publisher American Chemical Society

Specialty Chemistry

Date 2006 Jul 13

PMID 16834361

Citations 48

Authors

Masakazu Fujio

Douglass Wu

Raquel Garcia-Navarro

David D Ho

Moriya Tsuji

Chi-Huey Wong

Affiliations

Soon will be listed here.

Abstract

Introduction of an aromatic group into the fatty acyl chain of alpha-GalCer modulates the activity and selectivity of IFN-gamma/IL-4 secretion through CD1d-mediated activation of NKT cells. Compound 14-16 are more potent than alpha-Galcer and biased for IFN-gamma than for IL-4. These new glycolipids may find use as adjuvants or as antimetastatic agents.

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