NKT Cells: Potential Targets for Autoimmune Disease Therapy?

Overview

Journal Tissue Antigens

Date 2002 Jul 30

PMID 12144618

Citations 13

Authors

K J L Hammond

D I Godfrey

Affiliations

Soon will be listed here.

Abstract

NKT cells represent a unique T cell lineage that recognize glycolipid antigens in the context of the non-classical MHC class I molecule CD1d. NKT cells are potent producers of immunoregulatory cytokines, and have been implicated in several different autoimmune diseases in mice and humans, including Type 1 diabetes, experimental autoimmune encephalomyelitis--a mouse model for multiple sclerosis, systemic lupus erythematosus, and scleroderma. This review will cover the evidence for an involvement for NKT cells in these autoimmune diseases, and discuss the potential for therapeutic manipulation of these cells as a means of preventing autoimmune disease in the clinic.

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