Mitchell Kronenberg
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Explore the profile of Mitchell Kronenberg including associated specialties, affiliations and a list of published articles.
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252
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14614
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Recent Articles
1.
Li Y, Ascui G, Dicker M, Riffelmacher T, Chandra V, Schmiedel B, et al.
Nat Commun
. 2025 Mar;
16(1):2577.
PMID: 40089498
Genome wide association studies (GWAS) identify many risks for Crohn's disease (CD), including a site near the metabolism gene laccase domain containing 1 (LACC1). We previously found this site near...
2.
Ascui G, Cedillo-Castelan V, Mendis A, Phung E, Liu H, Verstichel G, et al.
J Immunol
. 2025 Mar;
214(2):223-237.
PMID: 40073243
A fundamental dichotomy in lymphocytes separates adaptive T and B lymphocytes, with clonally expressed antigen receptors, from innate lymphocytes, which carry out more rapid responses. Some T cell populations, however,...
3.
Kronenberg M, Riffelmacher T
Curr Opin Immunol
. 2025 Feb;
93:102542.
PMID: 40020256
Mucosal-associated invariant T (MAIT) cells recognize microbial riboflavin metabolites presented by MR1, a major histocompatibility complex class I-like protein. Activated MAIT cells produce cytokines such as interferon gamma (IFNγ), tumor...
4.
Kronenberg M, Ascui G
J Exp Med
. 2024 Dec;
222(2).
PMID: 39714312
In this issue of JEM, Hosono et al. (https://doi.org/10.1084/jem.20240728) characterize a putative self- glycolipid that engages the iNKT cell TCR when bound to CD1d. The expression and distribution of this...
5.
Adegoke A, Thangavelu G, Chou T, Petersen M, Kakugawa K, May J, et al.
Open Biol
. 2024 Oct;
14(10):240178.
PMID: 39471840
Immunologic self-tolerance involves signals from co-inhibitory receptors. Several T cell co-inhibitors, including PD-1, are expressed upon activation, whereas CD5 and BTLA are expressed constitutively. The relationship between constitutively expressed co-inhibitors...
6.
Mathews I, Saminathan P, Henglin M, Liu M, Nadig N, Fang C, et al.
medRxiv
. 2024 Aug;
PMID: 39148854
Immune related adverse events (irAEs) after immune checkpoint blockade (ICB) therapy occur in a significant proportion of cancer patients. To date, the circulating mediators of ICB-irAEs remain poorly understood. Using...
7.
Li Y, Ramirez-Suastegui C, Harris R, Castaneda-Castro F, Ascui G, Perez-Jeldres T, et al.
Nat Immunol
. 2024 Jun;
25(7):1231-1244.
PMID: 38898157
To understand the role of T cells in the pathogenesis of ulcerative colitis (UC), we analyzed colonic T cells isolated from patients with UC and controls. Here we identified colonic...
8.
Kamii Y, Hayashizaki K, Kanno T, Chiba A, Ikegami T, Saito M, et al.
Proc Natl Acad Sci U S A
. 2024 Feb;
121(9):e2313964121.
PMID: 38394242
Invariant natural killer T (iNKT) cells are innate-like T lymphocytes that express an invariant T cell receptor α chain and contribute to bridging innate and acquired immunity with rapid production...
9.
Kronenberg M, Engel I
J Clin Invest
. 2024 Feb;
134(4).
PMID: 38357925
NKT cells recognize glycolipids presented by CD1d-expressing antigen-presenting cells (APCs) and include type I NKT cells with antitumor function and type II NKT cells, which have been reported to suppress...
10.
Perez-Jeldres T, Magne F, Ascui G, Alvares D, Orellana M, Alvarez-Lobos M, et al.
Front Med (Lausanne)
. 2023 Nov;
10:1258395.
PMID: 37964883
Background And Aims: Latin American populations remain underrepresented in genetic studies of inflammatory bowel diseases (IBDs). Most genetic association studies of IBD rely on Caucasian, African, and Asian individuals. These...