Zhao-Peng Liu
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Explore the profile of Zhao-Peng Liu including associated specialties, affiliations and a list of published articles.
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58
Citations
353
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Recent Articles
1.
Jiang H, Liu X, Zhao D, Jia Y, Wang Y, Li W, et al.
Anal Chem
. 2024 Dec;
96(52):20656-20664.
PMID: 39699555
Microelectrode- and nanoelectrode-based electrochemistry has become a powerful tool for the in situ monitoring of various biomolecules in vivo. However, two challenges limit the application of micro- and nanoelectrodes: the...
2.
Jiang H, Jia Y, Wang Y, Liu X, Li W, Liu Z, et al.
ACS Sens
. 2024 Sep;
9(9):4956-4962.
PMID: 39283684
Natural products play a significant role in new drug discovery and anticancer therapy, making the evaluation of their anticancer efficiency crucial for clinical application. However, delivering natural products to single...
3.
Yan N, Liu H, Kong T, Kong Z, Li L, Ma X, et al.
Bioorg Med Chem Lett
. 2024 Aug;
112:129932.
PMID: 39182737
Glycogen synthase kinase 3β (GSK-3β) is a potential therapeutic target for the treatment of a variety of human diseases. Here, we report the design and synthesis of a series of...
4.
Xu Y, Qian L, Fang M, Liu Y, Xu Z, Ge X, et al.
Eur J Med Chem
. 2023 Aug;
259:115693.
PMID: 37531745
Epothilone B (Epo B) is a potent antitumor natural product with sub-nanomolar anti-proliferation action against several human cancer cells. However, poor selectivity to tumor cells and unacceptable therapeutic windows of...
5.
Yan N, Xie F, Tang L, Wang D, Li X, Liu C, et al.
Bioorg Chem
. 2023 Jun;
138:106663.
PMID: 37329814
Glycogen synthase kinase 3β (GSK-3β) is a potential target for anti-Alzheimer's disease (AD) drug development. In this study, a series of novel thieno[3,2-c]pyrazol-3-amine derivatives was synthesized and evaluated as potential...
6.
Wen Z, Wang M, Li L, Herdewijn P, Snoeck R, Andrei G, et al.
Bioorg Chem
. 2023 Apr;
135:106527.
PMID: 37031504
β-D-N-hydroxycytidine (NHC, EIDD-1931) is a nucleoside analogue that exhibits broad spectrum antiviral activity against a variety of RNA viruses. Herein, we report the synthesis of a series of lipid prodrugs...
7.
Yan N, Shi X, Tang L, Wang D, Li X, Liu C, et al.
J Enzyme Inhib Med Chem
. 2022 Jun;
37(1):1724-1736.
PMID: 35698879
Glycogen synthase kinase 3β (GSK-3β) catalyses the hyperphosphorylation of tau protein in the Alzheimer's disease (AD) pathology. A series of novel thieno[3,2-]pyrazol-3-amine derivatives were designed and synthesised and evaluated as...
8.
Chen L, Liu Z, Li X
ChemMedChem
. 2022 Feb;
17(6):e202100731.
PMID: 35146935
The epigenetic reader BRD4 is involved in chromatin remodelling and transcriptional regulation, making it a promising therapeutic target. However, over the past decades, many BRD4 inhibitors that entered clinical trials...
9.
Li S, Zhang C, Wu J, Liu C, Liu Z
Eur J Med Chem
. 2021 Dec;
228:114037.
PMID: 34883290
Off-target toxicity is one of the main challenges faced by anticancer chemotherapeutics. For tumor targeted and precision chemotherapy, we take the advantages of the ligand directed tumor active targeting of...
10.
Liu C, Xu Y, Wen Z, Dong Y, Liu Z
Bioorg Med Chem Lett
. 2021 Nov;
55:128474.
PMID: 34838651
BU-4664L is a naturally occurring N-farnesylated dibenzodiazepinone with important biological activities. Herein, we report the synthesis and antitumor evaluation of two series of BU-4664L derivatives bearing different substituent patterns on...