Ren-Zhong Wan
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Explore the profile of Ren-Zhong Wan including associated specialties, affiliations and a list of published articles.
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Articles
12
Citations
101
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Recent Articles
1.
Chen L, Sun C, Feng G, Cao M, Zhao S, Yan J, et al.
Org Biomol Chem
. 2018 Apr;
16(15):2792-2799.
PMID: 29611855
An efficient oxidative C-H alkynylation of N-carbamoyl tetrahydroisoquinolines mediated by a TEMPO oxoammonium salt has been established. A variety of electronically varied N-carbamoyl tetrahydroisoquinolines reacted with a range of alkynyl...
2.
Gong Y, Wan R, Liu Z
Expert Opin Ther Pat
. 2017 Nov;
28(2):167-171.
PMID: 29166791
There are considerable interests in the development of novel small-molecule CD73 inhibitors for the treatment of cancers, autoimmune diseases, precancerous syndromes, and other diseases associated with CD73 activity. Areas covered:...
3.
Wang X, Wan R, Liu Z
Eur J Med Chem
. 2017 Nov;
143:1406-1418.
PMID: 29133060
Histone deacetylase HDAC6, a member of the class IIb HDAC family, is unique among HDAC enzymes in having two active catalytic domains, and has unique physiological function. In addition to...
4.
Liu Z, Chen L, Li J, Liu K, Zhao J, Xu M, et al.
Org Biomol Chem
. 2017 Sep;
15(36):7600-7606.
PMID: 28861580
A modular and efficient method for the synthesis of α-substituted 1,2-dihydroquinolines is described. Under mild metal-free conditions, readily available N-carbamoyl 1,2-dihydroquinolines undergo oxidative C-H alkynylation, alkenylation, and allylation with a...
5.
Xie X, Wan R, Liu Z
ChemMedChem
. 2017 Jul;
12(15):1157-1168.
PMID: 28722301
Matrix metalloproteinase-13 (MMP-13) plays a key role in the degradation of type II collagen in cartilage and bone in osteoarthritis (OA). The subtle differences between the S1' loop of MMP-13...
6.
Yin B, Li J, Wang S, Yan S, Sui C, Wan S, et al.
Eur J Drug Metab Pharmacokinet
. 2014 Oct;
41(1):19-25.
PMID: 25323694
Veterinary medicine plays a significant role in the development of animal husbandry. Drugs residual in food would follow the food-chain coming into human body, which might bring hidden dangers to...
7.
Ma C, Li H, Wan R, Liu Z
Mini Rev Med Chem
. 2014 Oct;
PMID: 25307307
Repair of DNA double-strand breaks (DSBs) is critical for the maintenance of genome integrity, cell survival, and prevention tumorigenesis. Three pathways are responsible for the repair of DNA DSBs: homologous...
8.
Zhao G, Wan R, Liu Z
Curr Med Chem
. 2014 Mar;
21(23):2691-701.
PMID: 24606497
Kinesin spindle protein (KSP) plays an essential role in centrosome separation and formation of the bipolar mitotic spindle. Its exclusive involvement in the mitotic spindle of proliferating cells presents an...
9.
Liu Y, Wan R, Liu Z
Mini Rev Med Chem
. 2013 Nov;
13(14):2047-59.
PMID: 24195664
The phosphoinositide 3-kinases (PI3Ks) are lipid kinases that play a central role in control of cell growth, proliferation, migration, survival and angiogenesis, and drive the progression of tumors by activating...
10.
Zhang C, Wan R, Liu Z
ChemMedChem
. 2013 Jun;
8(8):1249-60.
PMID: 23788554
The vitamin D hormone, 1α,25-dihydroxyvitamin D3 [1,25-(OH)2 D3 ], exerts its hormonal effects predominantly on intestine, bone, and kidney, where it plays a crucial role in calcium and phosphorus homeostasis...