Zachary A Bacigalupa
Overview
Explore the profile of Zachary A Bacigalupa including associated specialties, affiliations and a list of published articles.
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8
Citations
101
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Recent Articles
1.
Arner E, Jennings E, Crooks D, Ricketts C, Wolf M, Cottam M, et al.
bioRxiv
. 2025 Jan;
PMID: 39829901
Metastasis causes most cancer deaths and reflects transitions from primary tumor escape to seeding and growth at metastatic sites. Epithelial-to-mesenchymal transition (EMT) is important early in metastasis to enable cancer...
2.
Bacigalupa Z, Arner E, Vlach L, Wolf M, Brown W, Krystofiak E, et al.
J Clin Invest
. 2024 Jun;
134(12).
PMID: 38941296
Clear cell renal cell carcinoma (ccRCC) is an aggressive cancer driven by VHL loss and aberrant HIF-2α signaling. Identifying means to regulate HIF-2α thus has potential therapeutic benefit. Acetyl-CoA synthetase...
3.
Bacigalupa Z, Landis M, Rathmell J
Cell Metab
. 2023 Dec;
36(1):10-20.
PMID: 38118440
Cells in multicellular organisms experience diverse neighbors, signals, and evolving physical environments that drive functional and metabolic demands. To maintain proper development and homeostasis while avoiding inappropriate cell proliferation or...
4.
Greenwood D, Ramsey H, Nguyen P, Patterson A, Voss K, Bader J, et al.
Immunohorizons
. 2022 Dec;
6(12):837-850.
PMID: 36547387
Hematopoiesis integrates cytokine signaling, metabolism, and epigenetic modifications to regulate blood cell generation. These processes are linked, as metabolites provide essential substrates for epigenetic marks. In this study, we demonstrate...
5.
Ciraku L, Bacigalupa Z, Ju J, Moeller R, Le Minh G, Lee R, et al.
Oncogene
. 2022 Feb;
41(14):2122-2136.
PMID: 35190642
Glioblastomas (GBMs) preferentially generate acetyl-CoA from acetate as a fuel source to promote tumor growth. O-GlcNAcylation has been shown to be elevated by increasing O-GlcNAc transferase (OGT) in many cancers...
6.
Bacigalupa Z, Rathmell W
Nat Metab
. 2021 Nov;
3(11):1439-1440.
PMID: 34764458
No abstract available.
7.
Bacigalupa Z, Rathmell W
Cancer Lett
. 2020 Jun;
489:19-28.
PMID: 32512023
The relationship between kidney cancer, specifically clear cell renal cell carcinoma (ccRCC), and the hypoxia signaling program has been extensively characterized. Its underlying role as the primary driver of the...
8.
Akella N, Le Minh G, Ciraku L, Mukherjee A, Bacigalupa Z, Mukhopadhyay D, et al.
Mol Cancer Res
. 2020 Jan;
18(4):585-598.
PMID: 31974291
Breast tumors are heterogeneous and composed of different subpopulation of cells, each with dynamic roles that can change with stage, site, and microenvironment. Cellular heterogeneity is, in part, due to...
9.
Bacigalupa Z, Bhadiadra C, Reginato M
J Bioenerg Biomembr
. 2018 Jan;
50(3):189-198.
PMID: 29344764
Elevated O-GlcNAcylation is emerging as a general characteristic of most cancers. Although O-GlcNAcylation can regulate many cell biological pathways, recent evidence suggests that it is a key regulator of metabolic...