Yukio Hitotsuyanagi
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Explore the profile of Yukio Hitotsuyanagi including associated specialties, affiliations and a list of published articles.
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49
Citations
204
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Recent Articles
1.
Kitahara K, Mizushima H, Ogura K, Kato M, Fukaya H, Hasuda T, et al.
J Org Chem
. 2024 Oct;
89(22):16936-16946.
PMID: 39476362
RA-III acetate was treated with Lawesson's reagent to afford [Tyr-3-Ψ(CS-NH)-Ala-4]RA-III acetate. Treatment of this product with Hg(OAc)/LiCO and then methanol gave an oxazole intermediate. Acid-catalyzed arylation of the methylene carbon...
2.
Asai H, Kato K, Miyasaka M, Hatsukawa K, Murakami N, Takeda N, et al.
Int Arch Allergy Immunol
. 2024 May;
185(9):836-847.
PMID: 38797160
Introduction: Kamebakaurin is an active constituent of both Rabdosia japonica and Rabdosia excisa, which are utilized in Chinese traditional medicine for improving symptoms in patients with allergies. We investigated the...
3.
Hitotsuyanagi Y
Yakugaku Zasshi
. 2024 May;
144(5):553-565.
PMID: 38692932
A series of antitumor bicyclic hexapeptide RA-VII analogues modified at residue 2, 3, or 6 were prepared by the chemical transformation of the hydroxy, methoxy, or carboxy groups or the...
4.
Aoyagi Y, Tomita K, Kobayashi A, Nakamura A, Fujii Y, Yagi M, et al.
Bioorg Med Chem Lett
. 2023 Jan;
82:129149.
PMID: 36690039
A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer...
5.
Yun Y, Nakano T, Fukaya H, Hitotsuyanagi Y, Nakamura M, Umetsu M, et al.
Molecules
. 2022 May;
27(9).
PMID: 35566260
Retusone A (), a new sesquiterpene dimer consisting of two guaiane-type sesquiterpenoids, and oleodaphnal () were isolated from heartwood of (Thymelaeaceae). The planar structure of was elucidated on the basis...
6.
Aoyagi Y, Fujiwara K, Takahashi Y, Yano R, Hitotsuyanagi Y, Takeya K, et al.
Chem Pharm Bull (Tokyo)
. 2022 Apr;
70(4):300-303.
PMID: 35370208
A p-quinone analog having the komaroviquinone pharmacophore fused with a more conformationally flexible cycloheptane ring, was semisynthesized from natural demethlsalvicanol isolated from Perovskia abrotanoides via four steps in 26% overall...
7.
Hitotsuyanagi Y
J Nat Med
. 2021 Jul;
75(4):752-761.
PMID: 34244894
The 14-membered cycloisodityrosine is the core structure of RA-series antitumor bicyclic peptides obtained from Rubia plants (Rubiaceae). In this study, an efficient method for the synthesis of cycloisodityrosines from commercially...
8.
Yun Y, Shioura M, Hitotsuyanagi Y, Yotsumoto S, Takahashi Y, Aoyagi Y, et al.
Molecules
. 2021 Apr;
26(9).
PMID: 33919344
Cytotoxicity and apoptosis-inducing properties of compounds isolated from leaves were investigated. The hexane-soluble portion of MeOH extracts of leaves that showed cytotoxic activity was separated to yield seven compounds -....
9.
Muhamad M, Choo C, Hasuda T, Hitotsuyanagi Y
Fitoterapia
. 2019 Jul;
137:104256.
PMID: 31295513
Labisia pumila var. alata (Myrsinaceae) or "Kacip fatimah" is a famous Malay traditional herb used for the maintenance of women's health. The extracts of L.pumila displayed estrogenic activity in rats....
10.
Hitotsuyanagi Y, Hirai M, Odagiri M, Komine M, Hasuda T, Fukaya H, et al.
Chem Asian J
. 2018 Nov;
14(1):205-215.
PMID: 30393964
Two RA-series bicyclic hexapeptides, RA-XXV (4) and RA-XXVI (5), which have no N-methyl group at Tyr-5, were isolated from the roots of Rubia cordifolia L. Their amino acid compositions and...