Synthesis of 1-O-acyl- and 1-oxo-kamebanin Analogues and Their Cytotoxic Activity

A series of 1-O-acyl- and 1-oxo-kamebanin analogues were prepared from kamebanin, isolated from Rabdosia excisa and their cytotoxicity was assayed on HL60 promyelocytic leukemia cells and HCT116 human colon cancer cells. The structure-activity relationship study showed that the presence of 1-O-acyl groups of a C-C carbon chain increased the cytotoxic activity.