Yuchi Honaker
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Explore the profile of Yuchi Honaker including associated specialties, affiliations and a list of published articles.
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11
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411
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Recent Articles
1.
Honaker Y, Gruber D, Jacobs C, Cheng R, Patel S, Galvan C, et al.
Mol Ther
. 2024 Dec;
PMID: 39673129
Pathogenic long-lived plasma cells (LLPCs) secrete autoreactive antibodies, exacerbating autoimmune diseases and complicating solid organ transplantation. Targeted elimination of the autoreactive B cell pool represents a promising therapeutic strategy, yet...
2.
Cheng R, Helmers A, Kreuser S, Dahl N, Honaker Y, Lopez C, et al.
Cell Rep Methods
. 2024 Oct;
4(10):100878.
PMID: 39406231
A key step in developing engineered B cells for therapeutic purposes is evaluation in immunocompetent, large-animal models. Therefore, we developed methods to purify, expand, and differentiate non-human primate (NHP; rhesus...
3.
Singh S, Pugliano C, Honaker Y, Laird A, DeGottardi M, Lopez E, et al.
Mol Ther Methods Clin Dev
. 2024 Jan;
32(1):101183.
PMID: 38282895
Immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome is a monogenic disorder caused by mutations in the gene, required for generation of regulatory T (T) cells. Loss of T cells leads...
4.
Yang S, Singh A, Drow T, Tappen T, Honaker Y, Barahmand-Pour-Whitman F, et al.
Sci Transl Med
. 2022 Oct;
14(665):eabn1716.
PMID: 36197963
Adoptive transfer of regulatory T cells (T) is therapeutic in type 1 diabetes (T1D) mouse models. T that are specific for pancreatic islets are more potent than polyclonal T in...
5.
Honaker Y, Hubbard N, Xiang Y, Fisher L, Hagin D, Sommer K, et al.
Sci Transl Med
. 2020 Jun;
12(546).
PMID: 32493794
Thymic regulatory T cells (tT) are potent inhibitors of autoreactive immune responses, and loss of tT function results in fatal autoimmune disease. Defects in tT number or function are also...
6.
Hale M, Lee B, Honaker Y, Leung W, Grier A, Jacobs H, et al.
Mol Ther Methods Clin Dev
. 2017 Mar;
4:192-203.
PMID: 28345004
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful...
7.
Li P, Silvis M, Honaker Y, Lien W, Arron S, Vasioukhin V
Genes Dev
. 2016 Mar;
30(7):798-811.
PMID: 27013234
Cell-cell adhesion protein αE-catenin inhibits skin squamous cell carcinoma (SCC) development; however, the mechanisms responsible for this function are not completely understood. We report here that αE-catenin inhibits β4 integrin-mediated...
8.
Teasley D, Parajuli S, Nguyen M, Moore H, Alspach E, Lock Y, et al.
J Biol Chem
. 2015 Apr;
290(24):15133-45.
PMID: 25922071
The existence of redundant replication and repair systems that ensure genome stability underscores the importance of faithful DNA replication. Nowhere is this complexity more evident than in challenging DNA templates,...
9.
Chen X, Kim I, Honaker Y, Paudyal S, Koh W, Sparks M, et al.
J Biol Chem
. 2015 Apr;
290(19):12300-12.
PMID: 25833945
The DNA end resection process dictates the cellular response to DNA double strand break damage and is essential for genome maintenance. Although insufficient DNA resection hinders homology-directed repair and ATR...
10.
Duxin J, Moore H, Sidorova J, Karanja K, Honaker Y, Dao B, et al.
J Biol Chem
. 2012 May;
287(26):21980-91.
PMID: 22570476
Dna2 is an essential helicase/nuclease that is postulated to cleave long DNA flaps that escape FEN1 activity during Okazaki fragment (OF) maturation in yeast. We previously demonstrated that the human...