Yu-Suke Torisawa
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Explore the profile of Yu-Suke Torisawa including associated specialties, affiliations and a list of published articles.
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41
Citations
1889
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Recent Articles
1.
Deguchi S, Kosugi K, Takeishi N, Watanabe Y, Morimoto S, Negoro R, et al.
Cell Stem Cell
. 2024 Jul;
31(9):1315-1326.e8.
PMID: 38996472
Recent advances have made modeling human small intestines in vitro possible, but it remains a challenge to recapitulate fully their structural and functional characteristics. We suspected interstitial flow within the...
2.
Deguchi S, Kosugi K, Hashimoto R, Sakamoto A, Yamamoto M, Krol R, et al.
PNAS Nexus
. 2023 Mar;
2(3):pgad029.
PMID: 36896132
SARS-CoV-2 induces severe organ damage not only in the lung but also in the liver, heart, kidney, and intestine. It is known that COVID-19 severity correlates with liver dysfunction, but...
3.
Wang M, Tsuda M, Deguchi S, Higuchi Y, So K, Torisawa Y, et al.
Int J Pharm
. 2022 Oct;
627:122253.
PMID: 36183916
Recently, increasing attention has been paid to liver-on-a-chip models for both pharmacokinetics and toxicity (ADMET) screenings. Although polydimethylsiloxane (PDMS) is the most popular material for the fabrication of microfluidic devices,...
4.
Hashimoto R, Takahashi J, Shirakura K, Funatsu R, Kosugi K, Deguchi S, et al.
Sci Adv
. 2022 Sep;
8(38):eabo6783.
PMID: 36129989
In the initial process of coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infects respiratory epithelial cells and then transfers to other organs the blood vessels. It...
5.
Sano E, Deguchi S, Matsuoka N, Tsuda M, Wang M, Kosugi K, et al.
ACS Omega
. 2021 Oct;
6(38):24859-24865.
PMID: 34604667
Polydimethylsiloxane (PDMS) is widely used to fabricate microfluidic organs-on-chips. Using these devices (PDMS-based devices), the mechanical microenvironment of living tissues, such as pulmonary respiration and intestinal peristalsis, can be reproduced...
6.
Deguchi S, Tsuda M, Kosugi K, Sakamoto A, Mimura N, Negoro R, et al.
ACS Biomater Sci Eng
. 2021 Jul;
7(8):3648-3657.
PMID: 34283567
A liver-on-a-chip (liver-chip) is a microfluidic device carrying liver cells such as human hepatocytes. It is used to reproduce a part of liver function. Many microfluidic devices are composed of...
7.
Sone N, Konishi S, Igura K, Tamai K, Ikeo S, Korogi Y, et al.
Sci Transl Med
. 2021 Jul;
13(601).
PMID: 34233948
Mucociliary clearance is an essential lung function that facilitates the removal of inhaled pathogens and foreign matter unidirectionally from the airway tract and is innately achieved by coordinated ciliary beating...
8.
Sugimura R, Ohta R, Mori C, Li A, Mano T, Sano E, et al.
Biomed Microdevices
. 2020 May;
22(2):34.
PMID: 32377802
A fundamental limitation in the derivation of hematopoietic stem and progenitor cells is the imprecise understanding of human developmental hematopoiesis. Herein we established a multilayer microfluidic Aorta-Gonad-Mesonephros (AGM)-on-a-chip to emulate...
9.
Torisawa Y, Tung Y
Micromachines (Basel)
. 2020 Apr;
11(4).
PMID: 32244638
Recent advances in microsystems technology and cell culture techniques have led to the development of organ-on-chip microdevices to model functional units of organs [...].
10.
Sano E, Mori C, Matsuoka N, Ozaki Y, Yagi K, Wada A, et al.
Micromachines (Basel)
. 2019 Nov;
10(11).
PMID: 31752314
Organs-on-chips are microfluidic devices typically fabricated from polydimethylsiloxane (PDMS). Since PDMS has many attractive properties including high optical clarity and compliance, PDMS is very useful for cell culture applications; however,...